Texas NeuroAIDS Research Center

摘要 国家神经艾滋病组织联盟(NNTC)是一个合作的组织和数据资源计划， 得克萨斯州神经艾滋病研究中心(TNRC；B.Gelman，PI)自1998年成立以来一直参与其中。 NNTC的目的是纵向收集和分发关键的临床数据和组织标本- 跟踪HIV感染高危人群的HIV相关神经认知障碍(HAND)，支持 在广大神经艾滋病社区中，由研究人员发起的创新和变革性研究。全国过渡委员会 患者队列是独一无二的，因为它是艾滋病毒领域唯一以病理学为重点的纵向队列。这个 该联盟帮助提高了该领域研究的整体相关性。超越了提供组织 样本TNRC为研究人员提供了相关的体内生物标记物、病毒载量、基因表达 数据、神经病理变化和相关的手认知状态。这使临床和基础 科学水平的研究人员将这些关键措施纳入驱动机制的研究 手，艾滋病毒感染的相关病理效应，或潜在的手治疗靶点。在过去 NNTC已经支持了数百份研究报告和赠款申请，并将继续这样做 通向未来。目前TNRC申请的广泛目标是继续执行合作协议 与其他临床站点和NIH合作，提供来自当地招募的(德克萨斯人)艾滋病毒的此类资源 患者，并将这一当地资源集中于解决不断变化的和未来的神经艾滋病资源需求 社区。TNRC患者队列未来将专注于美国艾滋病毒人口的老龄化， 这可能有助于了解年龄如何影响艾滋病毒相关的神经心理和神经功能障碍。 TNRC将重点提供组织样本，以确定潜在的艾滋病毒宿主的特征 被病毒抑制的人的身体深处的隔间。申请继续提供支援以营运 德克萨斯NNTC诊所网站介绍了TNRC一般操作程序的所有方面。我们描述了 招募实践，神经心理评估，药物使用调查，神经医学方案，尸检 程序和标本库管理。我们提出了建议的战略，以帮助 为了实现整个联合体的目标，并与全国过渡委员会的其他单位取得协同作用。NNTC继续运营 而TNRC将对寻找治疗HAND、CNS老化的药物产生持久和积极的影响 潜伏的艾滋病毒蓄水池和许多其他与艾滋病毒相关的病理情况。

Abstract The National NeuroAIDS Tissue Consortium (NNTC) is a collaborative tissue and data resourcing program in which the Texas NeuroAIDS Research Center (TNRC; B. Gelman, PI) has participated since inception in 1998. The NNTC's purpose is to collect and distribute critical clinical data and tissue specimens from longitudinally- tracked HIV-infected individuals at high risk for HIV-associated neurocognitive disorders (HAND), to support innovative and transformative investigator-initiated research in the NeuroAIDS community-at-large. The NNTC patient cohort is unique because it is the sole pathology-focused longitudinal cohort in the HIV field. The consortium has helped to heightened the relevancy of research overall in the field. Beyond supplying tissue specimens the TNRC provides researchers access to relevant in vivo biomarkers, viral loads, gene expression data, neuropathological changes, and associated HAND cognitive status. This enables clinical and basic science-level researchers to incorporate these critical measures into investigations of the mechanisms driving HAND, HIV-associated pathological effects of HIV infection, or potential HAND therapeutic targets. In past cycles the NNTC has supported hundreds of research reports and grant applications, and would continue to do that into the future. The broad aim of the current TNRC application is to continue the cooperative agreement with other Clinical sites and the NIH, to provide such resources derived from locally-recruited (Texan) HIV patients, and to focus this local resource to address changing and future resource needs of the NeuroAIDS community. The TNRC patient cohort will focus in the future on the aging of the HIV population in the USA, which could inform about how age influences HIV-associated neuropsychological and neurological dysfunction. TNRC will emphasize providing tissue specimens to define the characteristics of the latent HIV reservoirs in the deep body compartments of virally suppressed people. Application for continued support to operate the Texan NNTC clinic site addresses all aspects of the general operating procedures of the TNRC. We describe recruiting practices, neuropsychological evaluations, substance use surveys, neuromedical protocols, autopsy procedure, and specimen repository management. We present proposed strategies to contribute to consortium-wide goals and to obtain synergy with the other units of the NNTC. Continued operation of NNTC and the TNRC will have a lasting and positive impact on the search for remedies for HAND, CNS aging, CNS latent HIV reservoirs and many other HIV-associated pathological conditions.