Mechanically-restricted percutaneous gene therapeutic solutions for heart failure.

我们已经开发了一种新的系统，用于将特定的基因局部输送到心脏，以改善衰竭心脏的收缩能力和功能。许多基因，出于毒性、清除或摄取的原因，需要直接输送到靶区，而不会溢出到体循环。我们的系统通过隔离靶器官的局部循环并以最小的系统损失和提高的递送和摄取效率直接递送药物来解决这些问题，同时将潜在的危险和有毒的全身影响降至最低。

We have developed a novel system for the localized delivery of specialised genes to the heart in order to improve contractility and function of a failing heart. Many genes, for reasons of toxicity, clearance, or uptake, require direct delivery to the target region without spillover to the systemic circulation. Our system addresses these issues by isolating the local circulation of the target organ and directly delivering the agent with minimal systemic loss and improved delivery and uptake efficiency, while minimizing potentially dangerous and toxic systemic effects.