Clinical Research Core (CRC)

WF OAIC临床研究核心（CRC）提供关键基础设施和研究者资源 对于成功进行临床研究至关重要，重点是老年人的身体功能和残疾 成年人了CRC与其他OAIC资源核心（生物成像、综合生物学和 生物统计学和研究信息系统核心）。儿童权利委员会将与他们密切合作， 研究教育部分（REC）支持的学者，OAIC试点研究，外部资助的研究，以及 OAIC研究发展项目与WF OAIC研究主题相关：整合影响 身体功能的新方法来治疗和预防残疾。 在威廉姆森、雷杰斯基和马什博士的持续领导下，CRC将协助领导层， 行政核心（LAC）、试点和探索性研究核心（PESC）以及REC，以确定 有前途的新的调查人员和计划，以帮助解决身体残疾的机制 并努力减少或消除与年龄相关的功能障碍。社区康复中心将提供“交钥匙”资源， 成功的临床研究，包括：1）与实验研究设计和实施相关的专业知识， 包括选择适当的结果衡量标准; 2）高效和有效的参与者招募; 3） 一个共同的评估组合，包括对理解不断变化的物理环境至关重要的关键措施， 功能; 4）采购（与综合生物学核心）的肌肉，脂肪和皮肤组织和血液 样本;以及5）协助早期职业研究者处理IRB和其他监管文件（与 PESC和REC）。在本周期，提供这些关键资源是我们及时 完成临床研究，发表结果，竞争新的独立资助赠款，以及 培养新的调查员。 在新周期的第一年，CRC将支持22项研究：4项REC学者项目，4项试点研究，2项 发展项目和12个外部支持项目。这些项目涵盖了广泛的OAIC- 主题研究，包括优化身体成分，以改善肥胖老年人的身体功能， 将CNS相关措施/概念纳入我们不断发展的身体功能和残疾模型， 整合新的措施，将衰老生物学的见解转化为临床研究。

The WF OAIC Clinical Research Core (CRC) provides the critical infrastructure and investigator resources essential for the successful conduct of clinical research focusing on physical function and disability in older adults. The CRC is well-integrated with the other OAIC Resource Cores (BioImaging, Integrative Biology, and Biostatistics and Research Information Systems Cores). Working closely with them, the CRC will support Research Education Component (REC)-supported Scholars, OAIC pilot studies, externally funded studies, and OAIC Research Development Projects related to the WF OAIC research theme: Integrating pathways affecting physical function for new approaches to disability treatment and prevention. Under the continued leadership of Drs. Williamson, Rejeski & Marsh, the CRC will assist the Leadership and Administrative Core (LAC), the Pilot and Exploratory Studies Core (PESC), and the REC in identifying promising new investigators and programs positioned to help to address the mechanisms of physical disability and work to reduce or eliminate age-related dysfunction. The CRC will provide `turn-key' resources critical for successful clinical research studies, including: 1) expertise related to experimental study design and conduct, including selection of appropriate outcome measures; 2) highly efficient and effective participant recruitment; 3) a common assessment battery incorporating key measures important to understanding changing physical function; 4) procurement (with the Integrative Biology Core) of muscle, adipose and skin tissue and blood samples; and 5) assisting early-career investigators with IRB and other regulatory filings (in collaboration with the PESC and REC). In the present cycle, provision of these key resources has been integral to our timely completion of clinical studies, publication of results, competition for new independently-funded grants, and development of new investigators. In the first year of the new cycle, the CRC will support 22 studies: 4 REC Scholar Projects, 4 Pilot studies, 2 Development Projects, and 12 Externally-Supported projects. These projects cover a broad range of OAIC- themed research, including optimizing body composition to improve physical function in obese older adults, incorporating CNS-relevant measures/concepts into our evolving model of physical function and disability, and integrating new measures that translate insights from the biology of aging into clinical research.