UAB Research and Education Program in Neuroscience

摘要 这是一项关于继续在亚拉巴马大学颁发R25研究教育奖的建议， 伯明翰（UAB）。该计划将支持在神经科学领域谁是追求职业生涯的居民 结合临床实践和研究，并促进他们作为医生科学家的发展。 在过去的二十年里，我们投入了大量的努力和资源， 神经系统在健康和疾病中的作用，其结果是知识的巨大扩展 涵盖了遗传学、基因组学、神经肿瘤学、神经化学、突触学、神经细胞学 可塑性、神经发育和行为。然而，很明显， 这些进步和应用对人类健康的影响。对下一代医学科学家的迫切需求 包括：i）将来自几个领域的关于神经系统的发现整合到多模态和多 维度框架;和ii）制定转化途径，将这些知识应用于重要的 生物医学和行为问题。 本次更新提案中令人振奋的新举措如下：1）大卫·斯坦德特博士 继续担任项目主任，但他已与新的副主任中野一郎博士合作; 2） 范围已经扩大，现在不仅包括神经病学、神经外科学和神经病理学， 也包括放射科和麻醉科住院医师，他们的工作领域与NINDS使命一致; 3） 导师围绕四个主题组织，即神经肿瘤学，神经退行性变，突触 可塑性，脑血管疾病; 4）教学成分得到加强，包括一个正式的课程， 实验的严谨性 项目主任和副主任都是具有既定轨道的医生科学家 研究和培训记录。该计划支持的居民将在他们的研究期间开始他们的研究。 住院医师培训，并继续它到一段时间的研究奖学金后住院。成员遍布 学科将从事为期两年的全职研究培训。他们的研究经验将是 通过结构化的指导计划沿着教学的支持，实验严谨，专业 技能培训、赠款写作和负责任的研究行为。该计划的目标是使 居民和研究员发展神经学研究的职业生涯，并准备他们成功地 竞争个人奖学金或指导职业发展奖。作为一个机构，UAB是 非常有能力进行神经科学的研究教育，并发展 医学科学家将应用今天的发现来解决明天的挑战。

Abstract This is a proposal for continuation of an R25 research education award at the University of Alabama at Birmingham (UAB). This program will support residents in neuroscience fields who are pursuing careers combining clinical practice and research, and foster their development as physician-scientists. Over the past two decades, considerable efforts and resources have been devoted to understanding nervous system function in health and disease, and the result has been a vast expansion of knowledge encompassing fundamental discoveries in genetics, genomics, neuro-oncology, neurochemistry, synaptic plasticity, neural development, and behavior. It is clear, however, that there remains an unmet gap between these advances and applications to human health. A pressing need for next-generation physician-scientists includes: i) integrate discoveries about the nervous system from several domains into multi-modal and multi- dimensional frameworks; and ii) formulate translational pathways to apply this knowledge to important biomedical and behavioral problems. The new and exciting initiatives in this renewal proposal are as follows: 1) Dr. David Standaert continues as Program Director, but he has been teamed with the new Associate Director, Dr. Ichiro Nakano; 2) the scope has been expanded and now includes not only neurology, neurosurgery, and neuropathology but also radiology and anesthesiology residents who are working areas consistent with the NINDS mission; 3) the mentors have been organized around the four themes, that is, neuro-oncology, neurodegeneration, synaptic plasticity, and cerebrovascular disease; 4) didactic components are strengthened, including a formal course in experimental rigor. The Program Director and Associate Director are both physician-scientists with established track records in research and training. Residents supported by this program will initiate their research during their residency training, and continue it into a period of research fellowship following residency. Participants from all disciplines will engage in a total of two years in full time research training. Their research experience will be supported by a structured mentoring program along with didactic teaching in experimental rigor, professional skills training, grant writing, and responsible conduct of research. The goal of the program will be to enable residents and fellows to develop a career in neurological research, and to prepare them to successfully compete for individual fellowships or mentored career development awards. As an institution, UAB is exceptionally well positioned to undertake research education in the neurosciences, and to develop the physician-scientists who will apply today’s discoveries to solve the challenges of tomorrow.