Photoreceptor Function in ROP

项目总结 新生儿护理的进步提高了以前出生过的最小婴儿的存活率 期限(9个月)。早产对健康、视力和视网膜功能有长期影响。视网膜病变 早产儿(ROP)是一种早期活动性疾病，鉴于新生儿护理的改善，将一种 越来越多的婴儿面临终身眼睛问题的危险，包括视力低下和屈光不正 比如高度近视。据估计，早产儿的“失明年数” 命中注定可能等同于患有一些最常见的眼睛问题的成年人。一支由 具有互补专业知识的经验丰富的研究人员提出了一项儿童非侵入性研究的建议 有早产史，有或没有ROP，以填补视力、视网膜功能和 屈光不正。这些研究被组织成四个特定的目标，旨在测试关于ROP杆的假设 光感受器信号至受体后视网膜神经元(Aim 1)，结构与功能的关系 中央视网膜，包括中心凹，调节一些最重要的视觉功能(目标2)；以及 视网膜和脉络膜参数作为眼睛大小和屈光不正的决定因素的作用(目标3)。这些 实验遵循横断面设计，受试者(10岁至20岁)按ROP严重程度分层 (目标1和2)或按近视或正视分组(目标3)。一项针对婴儿的纵向研究(目标4) 严重的后部ROP病史将比较那些接受治疗的人的视觉、屈光和视网膜发育 一种玻璃体内抗血管内皮生长因子药物，用于激光切割周边视网膜的治疗。从长远来看 目标是实现对ROP疾病过程及其后果的新的理解，包括视觉 损害和高度屈光不正，尤其是高度近视。

PROJECT SUMMARY Advances in neonatal care have led to increased survival of even the tiniest infants who have been born before term (9 months). Prematurity has long term consequences for health, vision and retinal function. Retinopathy of prematurity (ROP) is an active disease in early infancy and, in view of the improved neonatal care, puts an increasing number of infants in jeopardy of lifelong eye problems including poor vision and refractive errors such as high myopia. It has been estimated that the number of “blind years” for which a preterm infant is destined may equal that encountered by adults with some of the most common eye problems. A team of experienced investigators with complementary expertise present a proposal for non-invasive studies in children with a history of prematurity, with or without ROP, to fill gaps in knowledge about vision, retinal function, and refractive error. The studies, organized into four Specific Aims, are designed to test hypotheses about ROP rod photoreceptor signals to post receptor retinal neurons (Aim 1), the structure to function relationships in the central retina that includes the fovea and mediates some of the most important visual functions (Aim 2); and the role of retinal and choroidal parameters as determinants of eye size and refractive error (Aim 3). These experiments follow a cross-sectional design with subjects (aged 10 to 20 years) stratified by ROP severity (Aims 1 and 2) or grouped by myopia or emmetropia (Aim 3). A longitudinal study (Aim 4) of infants with a history of severe posterior ROP will compare visual, refractive and retinal development in those treated using an intra-vitreal anti-VEGF agent to those treated using laser ablation of the peripheral retina. The long term objectives are to achieve new understanding of the ROP disease process and its aftermath including visual impairment and high refractive error, particularly high myopia.