International Collaboration to Develop Scalable Methods for Early Detection of Neurodevelopmental Disorder Due to Prenatal Alcohol Exposure

项目总结 早期识别受产前酒精暴露影响的儿童，即有胎儿酒精的儿童 频谱障碍(FASD)是启动早期干预的关键。早期干预可以利用 因此可以改善患有FASD的儿童的预后。但是，当前 测试幼儿神经发育障碍的方法在有效性和 管理成本很高。因此，许多儿童没有被认为患有FASD和适当的年龄 并且错过了有益的干预或治疗。鉴于FASD在世界各地的高患病率 在已经研究过这种障碍的地方，对患有FASD的儿童的更早和更准确的识别是非常重要的 公共卫生的重要性。建立在现有胎儿酒精谱系障碍合作倡议的基础上 (CIFASD)乌克兰纵向队列研究，我们将通过测试三种新技术来填补这一关键空白- 基于和可扩展的方法，可以识别幼儿的大脑功能障碍。这些小说 这些措施可以更早、更快、更准确、更经济地检测神经发育障碍。 因为产前饮酒。此外，正在测试的可伸缩方法具有全局

PROJECT SUMMARY Early identification of children who are affected by prenatal exposure to alcohol, i.e., who have Fetal Alcohol Spectrum Disorders (FASD), is essential to initiating early intervention. Early interventions can take advantage of neuroplasticity in young children and thus can improve outcomes for a child with FASD. However, current methods of testing young children for neurodevelopmental impairments are limited in their effectiveness and costly to administer. As a result, many children are not recognized as having FASD and years of appropriate and beneficial intervention or treatment are missed. Given the high prevalence of FASD in areas of the world where the disorder has been studied, earlier and more accurate recognition of children with FASD is of high public health importance. Building on the existing Collaborative Initiative on Fetal Alcohol Spectrum Disorders (CIFASD) longitudinal cohort study in Ukraine, we will fill this critical gap by testing three novel, technology- based and scalable methods that can identify impairments in brain functioning in young children. These novel measures can lead to earlier, rapid, more accurate, and cost-efficient detection of neurodevelopmental disorders due to prenatal alcohol. Furthermore, the scalable methods being tested have global