Older Americans Independence Center

总体：项目摘要 这是约翰霍普金斯大学老年美国人独立中心（JHU）的更新申请 审计和调查处）。在2013年开始的当前周期中，OAIC取得了广泛的成就， 为121份出版物和调查结果提供了投入，促进了48项额外赠款的供资，重点是 脆弱和衰老OAIC的研究人员试图通过这项研究促进老年人的独立性 的病因和临床后果的脆弱性，并通过翻译这方面的知识， 开发新的、以脆弱为重点的诊断、治疗和预防策略。该提案寻求 通过以下具体目标来实现这些目标：1）刺激和发展有效的以脆弱为中心的 跨学科研究计划; 2）将以脆弱为中心的知识转化为有针对性的 预防和治疗策略，帮助老年人保持独立; 3）提供重点， 向有兴趣发展职业生涯的初级调查员提供与虚弱相关的培训和指导 重点是保持老年人的独立性; 4）向OAIC支持的调查人员提供 生物统计学、生物学和临床科学领域的最高质量的跨学科专业知识和基础设施 与脆弱性研究相关; 5）支持创新方法的发展，研究战略 和脆弱性研究必不可少的技术;和6）吸引优秀的研究人员和学员， 来自约翰霍普金斯大学的脆弱性研究，并在当地推广他们的科学， 全国范围内。研究教育部分（REC）和试点研究核心将提供培训，导师， 以及为受资助的研究人员提供研究项目的咨询和物质支持。高度集成 资源核心集中在生物统计学，生物机制，临床翻译和招聘将 为支持的调查人员提供跨学科的专业知识，培训，指导，援助， 提供必要的服务，以执行杰出的以脆弱为重点的基础，临床和转化研究。一个新 信息传播核心将扩大研究人员开发的脆弱性研究结果的范围， 这个OAIC和超越，通过一个新的网站提供导航和方便地访问脆弱的结果， 创新的教育举措，与科学和专业组织建立新的伙伴关系， 实践社区和外联工作。该办公室将继续由一个长期的， 跨学科的，有成就的，高度可见的领导团队，他们继续发展一个持续的 为下一代脆弱科学的愿景，并致力于建立一个科学和文化 学者和实习生围绕脆弱的多样性社区。这个团队致力于开发下一个 产生所需的科学进步，并将由此产生的战略传播到实践和政策中， 将延长老年人的独立性。

Overall: Project Summary This is a renewal application for the Johns Hopkins University Older Americans Independence Center (JHU OAIC). In the current cycle that started in 2013, this OAIC has nurtured extensive accomplishment, contributing to 121 publications and findings that facilitated the funding of 48 additional grants focused on frailty and aging. Investigators in this OAIC seek to promote independence in older adults through the study of the etiologies and clinical ramifications of frailty and through the translation of this knowledge into the development of novel, frailty-focused diagnostic, treatment, and prevention strategies. This proposal seeks to achieve these goals through the following specific aims: 1) Stimulate and develop effective frailty-focused interdisciplinary research programs; 2) Translate the frailty-focused knowledge generated into targeted prevention and treatment strategies that help older adults maintain independence; 3) Provide focused and accessible frailty-related training and mentorship to junior investigators interested in developing careers focused on maintaining independence in older adults; 4) Provide to OAIC-supported investigators the highest quality interdisciplinary expertise and infrastructure in biostatistical, biological, and clinical science as relevant to frailty research; 5) Support the development of innovative methodologies, research strategies and technologies essential to the study of frailty; and 6) Attract outstanding investigators and trainees to frailty research from across the Johns Hopkins University and promote visibility of their science locally and nationally. A Research Education Component (REC) and Pilot Study Core will provide training, mentorship, and both advisory and material support for research projects for supported investigators. Highly integrated resource cores focused on biostatistics, biological mechanisms, and clinical translation and recruitment will provide supported investigators with the interdisciplinary expertise, training, mentorship, assistance, and services necessary to perform outstanding frailty-focused basic, clinical and translational research. A new Information Dissemination Core will extend the reach of findings on frailty developed by the researchers of this OAIC and beyond, through a new website providing navigation and easy access to findings on frailty, innovative educational initiatives, new partnerships with scientific and professional organizations, formation of communities of practice, and outreach efforts. This OAIC will continue to be directed by a long-standing, interdisciplinary, accomplished, and highly visible leadership team who continue to develop an ongoing vision for the next generation of frailty science and have worked to build a scientifically and culturally diverse community of scholars and trainees around frailty. This team is dedicated to developing the next generation of needed scientific advances and disseminating resulting strategies into practice and policy that will extend independence for older adults.