Yoga for Chemotherapy-induced Peripheral Neuropathy Treatment (YCT) Trial

项目总结 化疗引起的周围神经病变(CIPN)是最有害、最常见、最常见的疾病之一， 许多化疗药物有疼痛、致残和副作用，目前还没有有效的 对它的治疗。我们的试点IIB期双臂试验表明，瑜伽治疗与 与通常的护理对照组相比，减少了CIPN疼痛和跌倒的风险。我们的目标是 通过寻找有效的治疗方法来提高癌症患者的功能和生活质量 减轻化疗相关的毒副作用。拟议项目的目标是确定 瑜伽治疗CIPN疼痛、改善功能及改善感觉的疗效 神经恢复和降低癌症幸存者跌倒的风险 严重的CIPN疼痛。我们将进行第三阶段的随机教育和常规护理- 有268名参与者参加的对照试验：1)确定八周瑜伽的疗效 癌症存活者中重度CIPN疼痛的CIPN症状的治疗2) 评估瑜伽与教育控制和日常护理在提高灵活性和 降低跌倒的风险；以及3)评估瑜伽与教育控制和常规训练的效果 关注生活质量和感觉神经功能。

PROJECT SUMMARY Chemotherapy-induced Peripheral Neuropathy (CIPN) is one of the most harmful, common, painful, and disabling side effects of many chemotherapy agents and there is no effective treatment for it. Our pilot phase IIB two-arm trial showed that yoga treatment is associated with reduced CIPN pain and reduced risk of falls compared to usual care control. We aim to increase cancer patients’ function and quality of life by identifying effective treatments to alleviate chemotherapy-related toxicities. The goal of the proposed project is to determine the efficacy of yoga in treating CIPN pain and improving function, as well as to improve sensory nerve recovery and reduce the risk of falls in cancer survivors suffering from moderate to severe CIPN pain. We will conduct a phase III, randomized, education and usual care- controlled trial with 268 participants to: 1) determine the efficacy of an eight-week yoga treatment on CIPN symptoms among cancer survivors with moderate to severe CIPN pain; 2) evaluate the effect of yoga versus education control and usual care on improving flexibility and reducing the risk of falls; and 3) evaluate the effect of yoga versus education control and usual care on quality of life and sensory fiber functioning.