MECHANISTIC ROLE OF CHOLESTEROL IN NON-ALCOHOLIC STEATOHEPATITIS
MECHANISTIC ROLE OF CHOLESTEROL IN NON-ALCOHOLIC STEATOHEPATITIS
批准号:
nhmrc : 585411
负责人:
Prof Geoffrey Farrell
金额:
$35.58万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2010
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2010-01-01 至 2013-12-31
中文摘要
15%-30%的澳大利亚人患有脂肪肝,与肥胖、糖尿病和心脏病发作有关。三分之二的案例很容易逆转。其余的演变为非酒精性脂肪性肝炎(NASH),这是一种肝损伤,可能导致肝硬化和肝功能衰竭。这项研究试图找出为什么一些脂肪肝会导致NASH,以及NASH小鼠肝脏中积累的胆固醇是否是导致这种损害的原因。如果是这样的话,我们将找到通过饮食或药物治疗NASH的新方法。
英文摘要
Fatty liver is present in 15-30% of Australians, related to obesity, diabetes and heart attack. Two-thirds of cases reverse easily. The remainder evolve to non-alcoholic steatohepatitis (NASH), liver damage that can lead to cirrhosis and liver failure. This research seeks to find out why some cases of fatty liver lead to NASH, and whether cholesterol that accumulates in the livers of mice with NASH is what causes that damage. If so, we will find new ways to treat NASH by diet or drugs.
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Liver lipotoxicity and NASH: mechanistic roles of free cholesterol, saturated FFA, JNK1 and TLR4
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批准号:nhmrc : GNT1084136
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项目类别:Project Grants
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资助金额:$41.64万
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财政年份:2015
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负责人:Prof Geoffrey Farrell
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依托单位:
Liver lipotoxicity and NASH: mechanistic roles of free cholesterol, saturated FFA, JNK1 and TLR4
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批准号:nhmrc : 1084136
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项目类别:Project Grants
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资助金额:$28.65万
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财政年份:2015
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负责人:Prof Geoffrey Farrell
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依托单位:
Microparticles in NASH: origins, pathogenic roles, and biomarker of disease activity
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批准号:nhmrc : 1044288
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项目类别:Project Grants
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资助金额:$36.05万
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财政年份:2013
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负责人:Prof Geoffrey Farrell
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依托单位:
Significance of microparticles in the pathogenesis of liver ischemia reperfusion injury
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批准号:nhmrc : 1008958
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项目类别:Project Grants
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资助金额:$42.94万
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财政年份:2011
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负责人:Prof Geoffrey Farrell
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依托单位:
Protecting fatty livers from hepatic ischemia-reperfusion injury in liver surgery and transplantation
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批准号:nhmrc : 1010082
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项目类别:Project Grants
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资助金额:$41.67万
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财政年份:2011
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负责人:Prof Geoffrey Farrell
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依托单位:
MOLECULAR AND CELLULAR PATHOGENESIS OF HUMAN LIVER DISEASE
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批准号:nhmrc : 358398
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项目类别:Programs
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资助金额:$328.62万
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财政年份:2005
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负责人:Prof Geoffrey Farrell
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依托单位:
Preconditioning: the molecular basis for protection from hepatic ischemia-reperfusion injury
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批准号:nhmrc : 211137
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项目类别:NHMRC Project Grants
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资助金额:$27.14万
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财政年份:2002
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负责人:Prof Geoffrey Farrell
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依托单位:
ALCOHOL AND IMPAIRED LIVER REGENERATION: EFFECTS ON MITOGENIC SIGNALING PATHWAYS
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批准号:nhmrc : 107293
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项目类别:NHMRC Project Grants
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资助金额:$24.36万
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财政年份:2000
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负责人:Prof Geoffrey Farrell
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依托单位:
The mechanism of flucloxacillin hepatotoxicity
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批准号:nhmrc : 980063
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项目类别:NHMRC Project Grants
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资助金额:$11.33万
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财政年份:1998
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负责人:Prof Geoffrey Farrell
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依托单位:
Alcohol and calcium_signalling
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批准号:nhmrc : 970733
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项目类别:NHMRC Project Grants
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资助金额:$20.81万
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财政年份:1997
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负责人:Prof Geoffrey Farrell
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依托单位:
How anticancer drugs damage the liver
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批准号:nhmrc : 960917
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项目类别:NHMRC Project Grants
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资助金额:$8.63万
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财政年份:1996
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负责人:Prof Geoffrey Farrell
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依托单位:
How do drugs cause hepatitis and jaundice
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批准号:nhmrc : 940027
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项目类别:NHMRC Project Grants
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资助金额:$16.74万
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财政年份:1994
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负责人:Prof Geoffrey Farrell
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依托单位:
Liver enzymes and obstructed bile flow
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批准号:nhmrc : 920341
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项目类别:NHMRC Project Grants
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资助金额:$8.59万
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财政年份:1992
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负责人:Prof Geoffrey Farrell
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依托单位:
Alcohol and liver regeneration.
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批准号:nhmrc : 910837
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项目类别:NHMRC Project Grants
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资助金额:$7.25万
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财政年份:1991
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负责人:Prof Geoffrey Farrell
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依托单位:
Interferon alters the enzymes which break down drugs in the liver
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批准号:nhmrc : 910805
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项目类别:NHMRC Project Grants
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资助金额:$15.63万
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财政年份:1991
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负责人:Prof Geoffrey Farrell
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依托单位:
Understanding how anaesthetic gases can cause liver dam age in animals.
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批准号:nhmrc : 910840
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项目类别:NHMRC Project Grants
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资助金额:$9.37万
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财政年份:1991
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负责人:Prof Geoffrey Farrell
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依托单位:
Nikon inverted microscope diaphot
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批准号:nhmrc : 911206
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项目类别:NHMRC Infrastructure Grants
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资助金额:$1.91万
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财政年份:1991
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负责人:Prof Geoffrey Farrell
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依托单位:
Changes in special enzymes for drug breakdown in cirrho sis of the liver
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批准号:nhmrc : 900764
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项目类别:NHMRC Project Grants
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资助金额:$12.48万
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财政年份:1990
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负责人:Prof Geoffrey Farrell
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依托单位:
Changes in liver blood supply and sex hormone breakdown in rats and patients
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批准号:nhmrc : 890391
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项目类别:NHMRC Project Grants
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资助金额:$5.7万
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财政年份:1989
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负责人:Prof Geoffrey Farrell
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依托单位:
Interferon blocks excretion of other drugs
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批准号:nhmrc : 880220
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项目类别:NHMRC Project Grants
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资助金额:$5.95万
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财政年份:1988
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负责人:Prof Geoffrey Farrell
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依托单位:
海外基金