New mechanisms in axon regeneration

项目总结 轴突再生是神经系统的一项基本而保守的特性。但是轴突 神经损伤后，再生往往不能恢复功能。因此，该领域的一个关键问题是 以发现是什么决定了受损神经元重建功能回路的能力。这 一项提案研究了在受损神经元中发挥作用的新机制，并帮助 确定是否发生有效的再生。我们的长期目标是获得 全面了解将神经元损伤与成功联系起来的细胞功能 功能性再生。这个项目的具体目标是分析突触的过程 再生。该项目使用了体内方法的组合，旨在了解 突触再生是如何工作的，为什么它不能恢复正常功能，以及它是如何 改进了。完成这些目标将描述基本的细胞机制， 介导神经损伤后功能性轴突再生。

PROJECT SUMMARY Axon regeneration is a fundamental and conserved property of nervous systems. But axon regeneration often fails to restore function after nerve injury. Thus, a key question in the field is to discover what determines the capacity of injured neurons to rebuild functional circuits. This proposal investigates new mechanisms that function in the injured neuron and that help determine whether or not effective regeneration occurs. The long-term goal is to gain a comprehensive understanding of the cellular functions that link neuronal injury to successful functional regeneration. The specific goal of this project is to analyze the process of synapse regeneration. The project uses a combination of in vivo approaches aimed at understanding how synapse regeneration works, why it fails to restore normal function, and how it can be improved. Completion of these Aims will describe fundamental cellular mechanisms that mediate functional axon regeneration after nerve injury.