Cancer Epidemiology Cohort in Male Health Professionals

这一竞争性更新应用程序的目标是支持核心基础设施和卫生保健的后续行动， 专业人员随访研究（HPFS），一项由51，529名美国男性卫生专业人员组成的癌症流行病学队列研究 1986年基线年龄为40至75岁。这一队列的独特之处在于其对男性健康的关注， 随访，提供了一个必要的时间框架，以研究癌症发病率的可改变的风险因素， 轻泻药。定期更新有关饮食、体育活动、吸烟、体重、药物治疗和 其他可能改变的癌症风险决定因素。生物储存库是队列的关键要素， 包括DNA、红细胞、血浆、粪便和脚趾甲。已从7，522例事件中获得肿瘤组织 前列腺癌、结肠癌、膀胱癌、肾癌和肺癌（不吸烟者），以及血液系统癌症。队列 每两年周期的随访率始终为90%，死亡率随访几乎完成。目前， 21，853名参与者生活在癌症发病率较高的年龄;这些将是最具信息性的 提供了自中年以来广泛接触数据的病例。在目前的拨款中，发表了492篇论文，利用 来自HPFS的数据和/或生物样本;其中317例专门检查了癌症或前驱结果 其中包括由外部调查员领导的100多人。迄今为止，已有17，091名参与者被诊断患有癌症 4,704人死于癌症; 7,061名男性目前患有癌症。 在下一个供资周期，我们提出以下目标：目标1。积极跟进癌症 发病率和死亡率;更新癌症诊断前后的暴露情况;目标2。数据收集 癌症幸存者的生活质量，治疗，进展和大麻使用。目标3.更新食物 支持HPFS和外部研究的成分和营养数据库;联合校准膳食 调查问卷与南方社区队列研究（SCCS），以支持联合研究。目标4。到 维持和扩大HPFS组织生物储存库，以收集来自前列腺、结肠、肺、肾的组织， 膀胱癌;引导人工智能方法来表征前列腺的形态特征 肿瘤的目标5。维持其他生物储存库，包括血浆、红细胞、脚趾甲和生殖细胞 DNA.目标6。扩大HPFS和SCCS参与者地理编码地址的联系，以评估纵向 30年来的建筑环境和社区社会经济地位的措施。目标7。保持和 加强统计基础设施和数据管理，以支持内部和外部的HPFS分析 研究人员;开发新的软件，以促进HPFS中的潜伏期和竞争风险分析，并分享 外部调查员。目标8。促进与外部调查人员的资源共享和合作 和联盟，包括将HPFS调查问卷文件转移到安全的云环境中。与 额外的后续行动，包括癌症诊断后，HPFS仍然是理想的定位，使创新 通过确定一级和二级预防战略，为我们实现减少癌症负担的目标作出贡献。

The goal of this competing renewal application is to support the core infrastructure and follow-up of the Health Professionals Follow-up Study (HPFS), a cancer epidemiology cohort of 51,529 U.S. male health professionals age 40 to 75 years at baseline in 1986. This cohort is unique in its focus on men’s health and with 35 years follow-up, provides a time frame essential to study modifiable risk factors for cancer incidence with realistic latencies. Information has been regularly updated on diet, physical activity, smoking, weight, medications, and other potentially modifiable determinants of cancer risk. The biorepository is key element of the cohort and includes DNA, red blood cells, plasma, stool, and toenails. Tumor tissue has been obtained from 7,522 incident cancers of the prostate, colon, bladder, kidney, and lung (nonsmokers), and hematologic cancers. Cohort follow-up is consistently 90% at each two-year cycle and mortality follow-up is virtually complete. At present, 21,853 participants are living and at a heightened age of cancer incidence; these will be the most informative cases given extensive exposure data since midlife. In the current grant, 492 papers were published that utilize data and/or biological samples from HPFS; 317 of these specifically examined cancer or precursor outcomes including >100 led by external investigators. To date, 17,091 participants have been diagnosed with cancer and 4,704 cancer deaths have occurred; 7,061 men are currently living with a cancer diagnosis. In the next funding cycle, we propose the following aims: Aim 1. To actively follow-up for cancer incidence and mortality; to update exposures pre- and post-diagnosis of cancer; Aim 2. To collect data on quality of life, treatment, progression, and cannabis use among cancer survivors. Aim 3. To update the food composition and nutrient databases that support the HPFS and external studies; to jointly calibrate dietary questionnaires with the Southern Community Cohort Study (SCCS) to support combined studies. Aim 4. To maintain and expand the HPFS tissue biorepository to collect tissue from prostate, colon, lung, kidney, and bladder cancers; to pilot artificial intelligence approaches to characterize morphologic features of prostate tumors. Aim 5. To maintain other biorepositories including plasma, red blood cells, toenails, and germline DNA. Aim 6. To expand linkage of geocoded addresses of HPFS and SCCS participants to assess longitudinal measures of the built environment and neighborhood SES over three decades. Aim 7. To maintain and augment the statistical infrastructure and data management to support HPFS analyses by internal and external investigators; to develop new software to facilitate latency and competing risk analyses in HPFS and share with external investigators. Aim 8. To facilitate resource sharing and collaborations with external investigators and consortia, including the transfer of HPFS questionnaire datafiles onto a secure cloud environment. With additional follow-up, including after cancer diagnosis, the HPFS remains ideally positioned to make innovative contributions to our goal of reducing cancer burden by identifying primary and secondary prevention strategies.