Brief Research In Aging and Interdisciplinary Neurosciences (BRAIN)

项目摘要 哥伦比亚大学医学中心的神经病学系是多学科神经学研究的丰富场所，特别关注衰老神经系统和阿尔茨海默病及相关痴呆症（AD和ADRD）。该提案旨在继续为每年夏天参加衰老和跨学科神经科学简短研究（BRAIN）项目的20名临床前学生的职位提供资金。对于大脑计划，我们已经制定了一个全面的方法来开发一个正式的研究计划，为博士生在生物医学，行为和临床研究的职业生涯早期。这项工作是通过为这些学生提供简短但密集的暑期研究培训经验来进行合作。研究培训提供了基础，行为和临床研究的机会，通过在基础神经科学，神经病理学，神经遗传学，神经心理学，流行病学和临床试验领域正在进行的研究，重点是阿尔茨海默病和相关痴呆症，与衰老相关的运动神经元疾病，中风和癫痫，以及治疗这些疾病患者的神经学临床试验。纳入神经系统疾病进展的生物和认知标志物的方法，如脑淀粉样蛋白和tau蛋白，结构脑成像，以及记忆，执行功能和其他认知领域的评估嵌入培训课程。此外，一个全面的结构化研究教育课程是在密集的研究经验的过程中交付，主题包括良好的临床实践，基本研究方法，介绍摘要作者和海报演示，并介绍统计概念和方法分析，以及流行病学和病理生理学审查最常见的神经系统疾病，如阿尔茨海默氏病。我们的机构拥有世界各地发展学术神经学家的最佳记录，这个短期，紧张的计划建立在这丰富的资源基础上，通过动手介绍神经学研究，全面审查研究原则，从而确保这些学生有最好的机会在包括阿尔茨海默病在内的衰老神经系统疾病领域发展研究事业。

Project summary The Department of Neurology at Columbia University Medical Center serves as a rich site for multidisciplinary neurological research, with particular focus on the aging nervous system and Alzheimer’s disease and Related Dementias (AD and ADRD). This proposal seeks to continue funding for positions for 20 preclinical students participating in the Brief Research in Aging and Interdisciplinary Neurosciences (BRAIN) program each summer. For the BRAIN program, we have developed a comprehensive approach to develop a formal research program for predoctoral students early in developing careers in biomedical, behavioral and clinical research. The work is collaboratively approached through brief but intensive mentored summer research training experiences for these students. The research training provides opportunities in basic, behavioral and clinical research through ongoing research in the fields of basic neuroscience, neuropathology, neurogenetics, neuropsychology, epidemiology, and clinical trials, with a focus on Alzheimer’s disease and Related Dementias, aging-related motor neuron disease, stroke, and epilepsy, as well as neurologic clinical trials treating patients with these disorders. Methods for inclusion of biological and cognitive markers of neurological disease progression, such as cerebral amyloid and tau, structural brain imaging, as well as assessment of memory, executive function, and other cognitive domains are embedded within the training curriculum. In addition, a comprehensive structured research education curriculum is delivered over the course of the intense research experience, with topics including good clinical practice, basic research methodologies, introductions to abstract authorship and poster presentations, and introduction of statistical concepts and approach to analyses, as well as epidemiologic and pathophysiologic reviews of the most common neurologic disorders such as Alzheimer’s disease. Our institution has the strongest track record of developing academic neurologists of anywhere worldwide, and this short-term, intense program builds upon this wealth of resources through hands-on introductions to neurological research, comprehensive review of principles of research, and thus assures the best opportunity for these students to develop research careers in the field of disorders of the aging nervous system including Alzheimer’s disease.