Pilot Projects Program

临床和转化性(C/T)研究在西弗吉尼亚州临床和转化性研究中扮演着重要角色 研究所(WVCTSI)网络。试点项目核心(PPC)的总体目标是增加 全州范围内由外部资助的C/T调查人员解决西弗吉尼亚州的健康问题。要实现 为了实现这一目标，PPC将实现三个具体目标：1) 提供支持竞争性试点的基础设施 为早期(ESI)和新调查人员(NI)提供资金机会，并随后指导进展至 项目完成、出版和外部资金申请，2)推进州内和州间合作 研究努力解决西弗吉尼亚州以及整个阿巴拉契亚地区的WVCTSI优先卫生地区 地区，以及3)实施发射台试点计划，以最大限度地扩大小说商业化的机会 科学。在目标1中，PPC将从以下方面征求和严格审查相关的C/T研究申请 WVCTSI调查人员。申请者将从项目启动到 出版物的准备和随后申请的外部资金。重点将是 分配给新的调查员(没有独立-R01级资金的调查员)和早期阶段 调查人员(在其职业生涯结束后接受10年教育，包括住院医师和研究员)。PPC将 聘请成功的高级研究人员担任两名科学高级顾问(一名临床医生科学家，另一名 翻译科学家)。这些高级顾问将通过与新的合作伙伴密切合作，帮助PPC完成指导任务 和早期调查人员，通过创建适当的指导团队来确保研究效率 与专业发展核心协作。PPC将优先安排试点奖项以促进 临床项目，特别是在农村社区开展的项目。在目标2中，PPC将促进内部和 针对WVCTSI优先卫生领域的国家间合作研究努力，通过具体的“请求 需要或包括来自多个WVCTSI合作伙伴的首席调查人员的申请“和计划。 PPC还将协助其他核心(例如社区参与和外联)进行重点研究 计划通过促进申请征集和审查。AIM 3将重点实施“发射”计划 PAD“试点计划在最初筹资周期的第四年进行了可行性测试。Launch Pad是一个 旨在加快研究人员在以下领域开发的知识产权翻译的创新计划 WVCTSI网络将转化为已实现的发明和专利，从而拓宽了潜在的资金来源。 总体而言，PPC倡议将显著推进西弗吉尼亚州C/T研究的进行，使其受益 所有西弗吉尼亚人和阿巴拉契亚地区人口的健康。

Clinical and translational (C/T) research plays a vital role within the West Virginia Clinical and Translational Institute (WVCTSI) network. The overall goal of the Pilot Project Core (PPC) is to increase the number of externally-funded C/T investigators across the state addressing West Virginia health issues. To achieve this goal, the PPC will accomplish three specific aims: 1) provide infrastructure supporting competitive pilot funding opportunities for early stage (ESI) and new investigators (NI) with subsequent mentored progression to project completion, publication, and external funding application, 2) advance intra- and inter-state collaborative research endeavors to address WVCTSI priority health areas within WV as well as throughout the Appalachian region, and 3) implement the Launch Pad Pilot Program to maximize opportunities for commercialization of novel science. In Aim 1, the PPC will solicit and rigorously review relevant C/T research applications from WVCTSI investigators. Applicants will receive intensive mentoring from project initiation through publication preparation and subsequent extramural funding of applications. Emphasis will be placed on new investigators (investigators with no independent - R01 level - funding) and Early Stage Investigators (< 10 years into their career post education, including medical residency and fellowships). PPC will engage successful senior investigators as two Scientific Senior Advisors (one a clinician scientist, the other a translational scientist). These Senior Advisors will aid PPC in its mentoring mission by working closely with new and early stage investigators to assure research productivity through the creation of appropriate mentoring teams in collaboration with the Professional Development Core. The PPC will prioritize pilot awards to promote clinical projects, particularly those conducted in rural communities. In Aim 2, the PPC will promote intra- and inter-state collaborative research efforts that target WVCTSI priority health areas through specific “requests for applications” and programs that require or include principal investigators from more than one WVCTSI partner. The PPC will also assist other Cores (e.g. Community Engagement and Outreach) with their focused research programs through facilitating application solicitation and review. Aim 3 will focus on implementing the “Launch Pad” pilot program that was tested for feasibility during Year 4 of the initial funding cycle. Launch Pad is an innovative program intended to accelerate the translation of intellectual property developed by researchers within the WVCTSI network into realized inventions and patents, thereby broadening the potential sources of funding. Collectively, the PPC initiatives will significantly advance the conduct of C/T research in West Virginia to benefit the health of all West Virginians and regional Appalachian populations.