West Virginia IDeA Network of Biomedical Research Excellence (WV-INBRE)

描述（由申请人提供）：西弗吉尼亚州是一个历史上获得美国国立卫生研究院拨款成功率较低的州，已被指定为 IDeA 州。马歇尔大学 (MU) 与西弗吉尼亚大学 (WVU) 合作荣获 IDeA 生物医学研究卓越网络 (INBRE) 奖 (WV-INBRE)，以帮助西弗吉尼亚州主要本科院校 (PUIs) 开展生物医学研究，并加强这些 PUI 学生进入生物医学研究领域作为职业的渠道。当前的 WV-INBRE 续签申请将建立在现有计划的成功基础上。为此，密西根大学将与西弗吉尼亚大学合作，作为由 11 所本科院校组成的研究网络的牵头机构。该网络的多学科研究主题将是细胞和分子生物学，重点是心血管疾病和癌症。四个 PUI 将容纳五个主要研究项目，两个 PUI 将为有前途的初级研究人员颁发教师研究发展奖 (FRDA)。另外五个 PUI 拥有符合 FRDA 资格的生物医学研究人员。这些学校共同构成了西弗吉尼亚州研究网络的核心。建立了行政、生物信息学和基因组核心，以促进合作机构科学家和学生的研究进展、指导和培训以及职业发展。成功的基于社区的参与性研究核心阿巴拉契亚心血管研究网络（ACoRN）将得到扩展。此外，将加强与西弗吉尼亚州 COBRE 的联系，并将启动与西弗吉尼亚州健康科学技术学院 (HSTA) 计划的互动。拟议的计划是为本科生提供研究机会，这将有助于为这些学生进入健康相关的研究职业提供渠道。将为没有重大项目的 PUI 生物医学研究人员提供额外的计划和支持，以增强他们的生物医学研究潜力。此外，通过提供大量讲习班、研讨会、研究培训和指导以及使用最先进的核心设施，WV-INBRE 将帮助增强西弗吉尼亚州劳动力的科学和技术知识基础。 公共卫生相关性（由申请人提供）：WV-INBRE 资助的研究项目将调查包括心血管疾病和癌症在内的多种人类健康问题。还提出了研究与药物生物转化和传染病相关问题的项目。该计划的一个重要推动力是加强本科生在生物医学科学研究领域选择职业的渠道。

DESCRIPTION (provided by applicant): West Virginia is a State that has had a historically low success rate in obtaining grant awards from the National Institutes of Health and has been designated as an IDeA State. Marshall University (MU), in partnership with West Virginia University (WVU), was awarded an IDeA Network of Biomedical Research Excellence (INBRE) award (WV-INBRE) to help develop biomedical research at WV primarily undergraduate institutions (PUIs) and to enhance the pipeline of students from these PUIs entering the biomedical research field as a career. The current WV-INBRE renewal application will build on the successes of the existing program. To this end, MU, in partnership with WVU, will serve as lead institutions to a research network consisting of eleven undergraduate institutions. The multi-disciplinary research theme for this network will be cellular and molecular biology with an emphasis on cardiovascular disease and cancer. Four PUIs will house five major research projects and two PUIs will have Faculty Research Development Awards (FRDAs) for promising junior investigators. Five additional PUIs have biomedical researchers eligible for FRDAs. Collectively, these schools comprise the heart of the WV research network. Administrative, Bioinformatics and Genomic Cores have been established to facilitate the research progress, mentoring and training, and career development of scientists and students at the partner institutions. The successful community-based participatory research core Appalachian Cardiovascular Research Network (ACoRN) will be expanded. In addition, ties to WV COBREs will be strengthened and interactions with WV's Health Science Technology Academy (HSTA) program will be initiated. Programs are proposed to provide research opportunities for undergraduates students that will help serve as a pipeline for these students into health related research careers. Additional programs and support for PUI biomedical research investigators without major projects will be made available to strengthen their biomedical research potential. In addition, through providing numerous workshops, seminars, research training and mentoring, and access to state-of-the-art core facilities, WV-INBRE will help enhance the science and technology knowledge base of the WV workforce. PUBLIC HEALTH RELEVANCE (provided by applicant): WV-INBRE sponsored research projects will investigate several human health issues including cardiovascular disease and cancer. Projects are also proposed that investigate issues related to drug biotransformation and infectious disease. An important thrust of this program is directed toward enhancing the pipeline of undergraduate students choosing a career in the biomedical science research field.