Nonhuman Primate Core

NHP核心-项目摘要/摘要 寨卡病毒在美洲的出现及其与胎儿死亡和出生的关系 缺陷是一个重大的公共卫生挑战。到目前为止，关于母婴传播是如何发生的，以及在先天性感染期间哪些因素影响胎儿病理，人们知之甚少。 因此，了解孕期寨卡病毒感染的病理生理学是至关重要的。的用法 孕期ZIKV感染的非人灵长类(NHP)模型将允许精细和全面地检查感染的病理和持续时间，以及先前存在的登革热病毒的影响 对感染的免疫，以及对感染的免疫反应；不可能在 人类。由于猕猴的相对相似性，NHP模型非常适用于这些研究 从怀孕到人类怀孕。非人灵长类(NHP)核心是 方案项目，并为所有三个项目提供直接支持。NHP核心将提供健康的 动物，协调和实施拟议的NHP实验的所有方面，建立和验证 怀孕和监测孕产妇和胎儿健康，进行尸检和详细的组织病理学检查 检查，评估新生儿结局，并为以下方面提供合规监督和生物安全培训 这三个项目都是。

NHP Core - Project Summary/Abstract The emergence of Zika virus (ZIKV) in the Americas and its association with fetal demise and birth defects represents a significant public health challenge. To date, very little is known about how maternal-fetal transmission occurs and what factors influence fetal pathology during congenital infection. Thus, understanding the pathophysiology of ZIKV infection during pregnancy is critical. The use of a nonhuman primate (NHP) model for ZIKV infection during pregnancy will allow finescale and comprehensive examination of the pathology and duration of infection, the influence of pre-existing dengue virus immunity on infection, and the immune response to infection; important studies that are not possible in humans. The NHP model is additionally ideal for these studies due to the relative similarity of macaque pregnancies to human pregnancies. The Non-Human Primate (NHP) Core is an integral component of the Program Project and provides direct support to all three Projects. The NHP Core will provide healthy animals, coordinate and implement all aspects of the proposed NHP experiments, establish and verify pregnancies and monitor maternal and fetal health, perform necropsies and detailed histopathological examinations, assess neonatal outcomes, and provide compliance oversight and biosafety training for all three Projects.