Limited Competition: National Biocontainment Laboratories (NBLs) Operations Support (UC7 Clinical Trial Not Allowed)

项目摘要/摘要 该项目的目标是维持加尔维斯顿国家实验室(GNL)的 作为NIAID生物防御设施网络的一部分的德克萨斯大学医学部 为NIAID资助的人提供最大限度的遏制研究设施 研究人员，来自全国和世界各地的学术合作者， 商业合作伙伴和其他适当的人。这项高遏制研究 基础设施和相关设施需要安全可靠地进行 促进治疗学、诊断学的发现和发展的研究 以及需要生物遏制的危险病原体的疫苗。这一独特的资源 也是教育下一代传染病专家的重要资源 对全球健康具有重要意义的疾病。GNL积极回应全国公众 通过在诊断方面提供快速协助、共享关键的 试剂，并有助于发现和发展有效的医学 对策。为了实现这一目标，GNL维护着专注于支持的核心 安全可靠的操作和维护最大限度遏制的研究 并为在以下领域工作的调查人员提供独特资源和工具 生物遏制，使他们能够快速、安全和可靠地应对新出现的问题 传染病和生物恐怖主义威胁。独特的功能包括能够 产生和量化实验动物从小鼠到非人类的气溶胶挑战 灵长类，获得节肢动物媒介群以支持人畜共患病传播 研究，以及将发现可视化的最先进的成像能力，等等 其他。GNL团队通力合作，开展基础和应用研究， 将原始发现从概念转变为最终产品开发、验证和 执照。

Project Summary/Abstract The goal of this project is to maintain the Galveston National Laboratory (GNL) at the University of Texas Medical Branch as a part of the NIAID Biodefense Facilities Network to provide access to maximum containment research facilities for NIAID funded investigators, academic collaborators from across the nation and around the world, commercial partners and others as appropriate. This high containment research infrastructure and associated facilities is required to safely and securely conduct research that will facilitate the discovery and development of therapeutics, diagnostics and vaccines for dangerous pathogens requiring biocontainment. This unique resource is also a critical resource to educate the next generation of experts in infectious diseases of global health importance. The GNL actively responds to national public health emergencies by providing rapid assistance in diagnostics, sharing of critical reagents, and contributing to the discovery and development of effective medical countermeasures. To achieve this goal, the GNL maintains cores focused on supporting safe and secure operations and maintenance of maximum containment research facilities and to provide unique resources and tools to investigators working in biocontainment to allow them to rapidly, safely and securely address emerging infectious diseases and bioterrorism threats. Unique capabilities include the ability to generate and quantify aerosol challenges of laboratory animals from mice to non-human primates, access to arthropod vector colonies to support zoonotic disease transmission studies, and state-of-the-art imaging capabilities to visualize findings, among many others. Working together, GNL teams conduct basic and applied research that can transition original discoveries from concept to final product development, validation and licensure.