BIOINFORMATICS

生物信息学核心摘要 生物信息学核心作为一个集中的资源，提供专家和及时的生物信息学 咨询、分析、协作研究、管理和培训解决方案， 生物医学数据，包括高通量数据。生物信息学核心将支持 INBRE IV：夏威夷全州研究与教育伙伴关系（HiSREP），提供强大的综合 生物信息学服务于研究、教育、调查和创新方法的创建。 在INBRE III期间，对生物信息学核心进行了重组，以更好地作为HiSREP的资源。 因此，我们取得了实质性的进展。我们观察到， 使用几乎所有HiSREP机构的生物信息学核心服务的用户（近5倍）。的 Bioinformatics Core成功地提供了生物信息学/生物统计学培训和教育机会 到HiSREP社区。在INBRE III期间，生物信息学基础设施也得到了显著加强。 具体来说，最近购买了一台Illumina NextSeq 500机器， HiSREP网络中基于下一代测序的研究。Cray CS300 超级计算机安装在UH ITS中心，生物信息学核心可以完全访问。 在INBRE IV中，生物信息学核心将继续作为网络的重要组成部分发挥作用。 具体而言，核心将通过三个关键方式为INBRE IV的目标做出贡献： 核心将促进获得初步数据，用于资助申请和随后的研究， HiSREP研究人员通过咨询实验设计和数据管理以及提供专业知识 生物信息学和生物统计学中的数据分析和解释;（ii）教育和培训： 生物信息学核心将提供生物信息学和生物统计学方面的教育，以及对职业生涯的支持 研究人员（学生和教师）的发展，以及;（iii）核心发展：生物信息学核心 将创造新的工具和方法，或重新利用现有的工具和战略，以加快在 科学在所有这些活动中，核心将与其他地方和国家生物信息学合作， 丹 为了实现这些目标，我们提出了四个具体目标：（1） 扩展生物信息学核心服务， 支持 HiSREP研究者的生物医学研究需求 在他们的研究中。(2)提供 为所有阶段的HiSREP研究学生提供生物信息学相关主题的教育和培训机会， 科学家和社区合作伙伴。(3)开发新的生物信息学工具以增强生物信息学 通过生物信息学核心的组合和扩展的专业知识的相互作用进行研究。(4)构建 通过与HiSREP的互动和合作，实现机构和社区研究的协同作用 伙伴

BIOINFORMATICS CORE SUMMARY The Bioinformatics Core serves as a centralized resource for providing expert and timely bioinformatics consulting, analysis, collaborative research, management, and training solutions for a broad range of biomedical data including high-throughput data. The Bioinformatics Core will support the specific aims of the INBRE IV: Hawaii Statewide Research & Education Partnership (HiSREP) by providing a strong and integrated bioinformatics service in research, education, investigation and creation of innovative methodologies. During INBRE III, the Bioinformatics Core was reorganized to better serve as a resource to the HiSREP community, and consequently made substantial progress. We observed an annual increase in the number of users (nearly 5-fold) utilizing the Bioinformatics Core services from almost all the HiSREP institutions. The Bioinformatics Core has successfully provided bioinformatics/biostatistics training and education opportunities to the HiSREP community. During INBRE III, the Bioinformatics infrastructure was also significantly enhanced. Specifically, an Illumina NextSeq 500 machine was recently purchased and will function to greatly accelerate the next generation sequencing-based research in the HiSREP network. In addition, a Cray CS300 Supercomputer was installed at UH ITS Center, to which the Bioinformatics Core has full access. In INBRE IV, the Bioinformatics Core will continue to function as an important component of the network. Specifically, the Core will contribute to INBRE IV objectives in three key ways: (i) Customized Services: the core will facilitate the acquisition of preliminary data for grant applications and subsequent research by HiSREP investigators via consultation on experimental design and data management as well as offer expertise in data analysis and interpretation in bioinformatics and biostatistics; (ii) Education and Training: the Bioinformatics Core will provide education in bioinformatics and biostatistics, as well as support for the career development of researchers (both students and faculty), and; (iii) Core Development: the Bioinformatics Core will create new tools and methods or repurpose existing tools and strategies to accelerate advances in the science. In all of these activities, the Core will work collaboratively with other local and national bioinformatics cores. To reach these goals, we propose four Specific Aims: (1) Expand Bioinformatics Core services to support biomedical research needs of HiSREP investigators in the performance of their research. (2) Provide education and training opportunities in bioinformatics-related topics to all stage HiSREP research students and scientists as well as community partners. (3) Develop novel bioinformatics tools to enhance bioinformatics research through the interactions of the combined and expanded expertise of the Bioinformatics Core. (4) Build institutional and community research synergy through the interaction and collaboration with the HiSREP partners.