Translational Imaging Shared Resource

翻译成像共享资源（TISR）的总体使命是提供最先进的 为Roswell Park的研究者提供临床前和转化成像服务， 有效的方式。该资源为用户提供了先进的成像方式，包括磁共振成像。 共振成像（MRI）、超声（US）、光声成像（派）、荧光和生物发光 成像（BLI）。该资源由两名博士教师领导，他们在临床前和临床方面拥有丰富的经验。 成像，是布法罗200英里内唯一的共享资源，允许多模式解剖和 小型和大型动物疾病模型的功能成像。TISR共为67名Roswell用户提供服务， 其中60个（90%）是CCSG成员，包括46个CCSG成员， CCSG成员没有同行审查的资金，从所有五个研究计划谁是进行基础和 肿瘤学、放射学和癌症治疗学的转化研究。这导致了4项专利和71 同行评审的出版物，包括顶级癌症和成像期刊上的几篇出版物。近5 多年来，TISR为41个NIH赠款和6个DoD赠款提供了成像服务。TISR还获得了两个 NIH S10共享仪器赠款，使其成像服务的扩展，包括国家的， 本发明涉及光学和光声成像方法。该资源为癌症中心成员提供24/7访问 以及培训如何应用非侵入性成像技术来满足他们的癌症研究需求。的 TISR的具体目标是：1）为Roswell Park研究人员提供最先进的体内研究 成像技术; 2）开发定制的成像协议和定量图像分析方案， 在小型和大型癌症动物模型中进行实验治疗的临床前试验; 3）建立 一个技术平台，促进成像方法的临床转化，以改善疾病检测， 患者的治疗监测。TISR操作的一个组成部分是持续评估 通过评估当前需求、现有技术的反馈， 癌症中心成员的用户和预期的未来研究需求。TISR的未来计划包括 升级现有的磁共振成像仪器，并扩大成像服务，包括PET/SPECT和CT。

The overall mission of the Translational Imaging Shared Resource (TISR) is to provide state-of-the-art preclinical and translational imaging services to investigators at Roswell Park in a time-efficient and cost- effective manner. The resource provides users access to advanced imaging modalities including magnetic resonance imaging (MRI), ultrasound (US), photoacoustic imaging (PAI), fluorescence and bioluminescence imaging (BLI). The resource is led by two PhD faculty with extensive experience in preclinical and clinical imaging, and is the only shared resource within 200 miles of Buffalo that allows for multimodal anatomic and functional imaging of small and large animal models of disease. TISR served a total of 67 Roswell users, of which 60 (90%) were CCSG members, including 46 CCSG members with peer reviewed funding and 14 CCSG members without peer reviewed funding from all five research programs who are conducting basic and translational investigations in oncology, radiology and cancer therapeutics. This has led to 4 patents and 71 peer-reviewed publications including several publications in top-tier cancer and imaging journals. In the past 5 years, TISR has provided imaging services for 41 NIH grants and 6 DoD grants. TISR was also awarded two NIH S10 shared instrumentation grants that enabled expansion of its imaging services to include state-of-the- art optical and optoacoustic imaging methods. The resource provides cancer center members 24/7 access to and training in the application of non-invasive imaging technologies for their cancer research needs. The specific aims of the TISR are to: 1) Provide Roswell Park investigators with access to state-of-the-art in vivo imaging technologies; 2) Develop customized imaging protocols and quantitative image analysis schemes to conduct preclinical trials of experimental therapeutics in small and large animal models of cancer; 3) Establish a technology platform that facilitates clinical translation of imaging methods for improved disease detection and therapy monitoring in patients. An integral part of TISR operations is the continual assessment of need for expanding and/or updating imaging technology through evaluation of current demand, feedback from existing users and anticipated future research needs of cancer center members. Future plans for TISR include upgrading the existing MRI instrumentation and expansion of imaging services to include PET/SPECT and CT.