Comparative Functional Genomics INBRE in Maine

总体项目摘要 缅因州INBRE（ME-INBRE）是由MDI领导的13个公共和私人机构组成的全州网络 生物实验室（MDIBL）。该网络由两个研究所（MDIBL和The杰克逊）组成 实验室），一所授予研究生学位的大学（缅因州大学），八所本科学院 和大学（贝茨、鲍登和科尔比学院，大西洋学院，缅因大学荣誉学院， 缅因州法明顿、缅因州马奇亚斯和缅因州普雷斯克岛），一所社区学院（南缅因州 社区学院）和一所外展大学（UMaine Fort肯特），所有这些大学都已确认他们的 通过信件和谅解备忘录做出承诺。第一代和非传统学生 在参加ME-INBRE学术机构的人中占很大比例;范围为16-63% 公共机构为9-22%，私人机构为9-22%。ME-INBRE的科学重点是比较功能基因组学 促进来自多个学科和机构的科学家和学生之间的合作， 生物信息学作为一个合作平台。James Coffman和Dustin Updike博士是首席研究员 项目协调员，分别。他们的教师指导，科学领导和行政 活动将得到一个高素质的管理人员和核心主任团队的支持和补充， 一个指导委员会和一个外部咨询委员会。发展研究计划 将促进杰出教师的研究和职业发展。通过竞争选拔的项目负责人 将包括INBRE研究员，他们将投入50%的精力用于研究项目和研究培训 来自主要本科院校（PUI）的教师，他们将投入15- 25%的精力进行试点项目， 为学生在PUI现场提供研究机会。将提供研究培训， 本科生和研究生通过旨在满足我们网络的不同需求的计划。 我们预计，将提供至少1,000个个人研究和研究培训经验， 本科生和研究生在五年的补助金期间。生物信息学核心将提供 在数据管理、计算基础设施、严谨性和再现性方面提供全面的咨询， 分析，以及通过研讨会，课程和指导研究经验的生物信息学培训。 研究培训和资源中心将协调核心设施资源的管理， 国家基础设施研究所资助的研究和研究培训方案。与缅因州COBREs和区域 IDEA计划将利用资源，增加多样性，并让学生和教师参与基本的， 翻译和临床研究的机会，将补充和扩展ME-INBRE的计划。的 行政核心将管理和协调所有活动，并将实施形成和总结 评估ME-INBRE方案和活动，以指导努力最大限度地发挥其效力。

OVERALL PROJECT SUMMARY The Maine INBRE (ME-INBRE) is a statewide Network of 13 public and private institutions led by the MDI Biological Laboratory (MDIBL). The Network is composed of two research institutes (MDIBL and The Jackson Laboratory), one graduate degree granting university (The University of Maine), eight undergraduate colleges and universities (Bates, Bowdoin, and Colby Colleges, College of the Atlantic, UMaine Honors College, UMaine Farmington, UMaine Machias, and UMaine Presque Isle), one community college (Southern Maine Community College), and one outreach university (UMaine Fort Kent), all of whom have confirmed their commitment through letters and Memoranda of Understanding. First generation and non-traditional students represent a substantial percentage of those attending ME-INBRE's academic institutions; the range is 16-63% for public and 9-22% for private institutions. ME-INBRE's scientific focus on comparative functional genomics fosters collaboration between scientists and students from multiple disciplines and institutions using bioinformatics as a collaborative platform. Drs. James Coffman and Dustin Updike are Principal Investigator and Program Coordinator, respectively. Their faculty mentoring, scientific leadership and administrative activities will be supported and complemented by a highly qualified team of administrators and Core Directors, a Steering Committee, and an External Advisory Committee. The Developmental Research Project Program will foster the research and career development of exceptional faculty. Competitively selected project leaders will include INBRE Investigators, who will devote 50% effort to a Research Project, and Research Training Faculty from primarily undergraduate institutions (PUI), who will devote 15- 25% effort to a Pilot Project that provides research opportunities for students on site at their PUI. Research training will be offered to undergraduate and graduate students through programs designed to meet the diverse needs of our Network. We anticipate that at minimum 1,000 individual research and research training experiences will be provided to undergraduate and graduate students during the five-year grant period. The Bioinformatics Core will provide comprehensive consulting in data management, computational infrastructure, rigor and reproducibility, and analysis, as well as bioinformatics training through workshops, courses, and mentored research experiences. The Research Training and Resources Core will coordinate management of core facility resources with INBRE-funded research and research training programs. Collaborations with Maine COBREs and regional IDeA programs will leverage resources, increase diversity, and engage students and faculty in basic, translational, and clinical research opportunities that will complement and extend ME-INBRE's programs. The Administrative Core will manage and coordinate all activities, and will implement formative and summative evaluation of ME-INBRE programs and activities to guide efforts at maximizing their effectiveness.