Core B: Study Design and Molecular Epidemiology Core

项目摘要 心血管疾病、中风和认知障碍/痴呆是死亡和残疾的主要原因， 它们有几个共同的起源。佛蒙特心血管和脑中心（Vermont Center for Cardiovascular and Brain） 佛蒙特大学的健康（VCCBH）COBRE将通过合作解决这些疾病。 research.这将由来自多个学科的不同科学家共同进行， 这些疾病的病理生物学和分子流行病学，以应对公共卫生挑战 由他们提出。COBRE的研究设计和分子流行病学核心（CORE B）将 支持中心的项目主任向独立地位发展。它将利用三十年来 佛蒙特大学临床和生物化学研究实验室的经验， 分子流行病学实验室和一个生物储存库的所在地，该生物储存库包含来自> 100，000人的约470万份样本 来自许多观察性队列研究和临床试验的研究参与者。核心将配备多- 学科项目主任，他们需要的技能，以进行他们的研究，应用创新的研究 设计和统计分析，并将其结果从实验室或临床研究环境转化为 人口研究背景和背景，而不管他们以前在流行病学方面的经验。我们的理念是 核心小组不仅应提供服务，还应培训调查人员，使其掌握所有关键的 核心提供的元素。因此，核心将为项目主任提供初步和持续的正式 就研究设计和统计方法提供意见（目标1）;就 生物样品采购、储存和分析，包括优化和故障排除分析性能 (Aim（2）支持他们向独立过渡，将他们与国家资源联系起来， 研究，使他们能够将他们的研究转化为临床环境（目标3）。核心联合董事，博士。 Neil Zakai和Peter Durda博士沿着核心生物统计学家将指导项目总监。Zakai博士是一位 血液学家和慢性病流行病学家，在多种类型的研究设计、生物统计学 方法复杂的数据和实验室操作，而Durda博士在分子生物学方面有丰富的经验， 实验室方法和流行病学。Zakai博士和Durda博士将共同提供个性化的援助， 项目主任和创新讲习班利用翻转课堂的方法。还将提供服务 试点补助金获得者将由机构承诺的资金支持，其他研究人员 在该中心的潜在的未来项目主任的管道发展计划，并对UVM的研究 社区使用收费服务模式。随着时间的推移，核心将成为可持续的，服务于 佛蒙特大学的心血管和神经血管研究社区。

PROJECT SUMMARY Cardiovascular disease, stroke and cognitive impairment / dementia are leading causes of death and disability, and they arise from several common antecedents. The proposed Vermont Center for Cardiovascular and Brain Health (VCCBH) COBRE at the University of Vermont will address these diseases employing collaborative research. This will be conducted by diverse scientists from multiple disciplines working together to understand the pathobiology and molecular epidemiology of these diseases in order to meet the public health challenges presented by them. The Study Design and Molecular Epidemiology Core (CORE B) of the COBRE will support the evolution of the Center's Project Directors to independent status. It will leverage three decades of experience of the Laboratory for Clinical and Biochemistry Research at the University of Vermont, a leading molecular epidemiology laboratory and home to a biorepository containing ~4.7 million samples from >100,000 research participants from many observational cohort studies and clinical trials. The core will equip the multi- disciplinary Project Directors with the skills they need to conduct their research applying innovative study designs and statistical analyses, and to translate their results from bench or clinical research settings to the population research setting and back, regardless of their prior experience in epidemiology. Our philosophy is that a Core should not only provide service but should train an investigator to be skilled in all of the key elements that the Core provides. Thus, the Core will provide Project Directors with initial and ongoing formal input on their study design and statistical approaches (Aim 1); advise Project Directors on all aspects of biosample procurement, storage, and analysis, including optimizing and troubleshooting assay performance (Aim 2); and support their transition to independence by connecting them with the resources of national studies that will allow them to translate their research to clinical settings (Aim 3). The Core co-directors, Dr. Neil Zakai and Dr. Peter Durda, along with Core biostatisticians, will guide the Project Directors. Dr. Zakai is a hematologist and chronic disease epidemiologist with expertise in many types of study designs, biostatistical approaches to complex data, and laboratory operations, while Dr. Durda has vast experience in molecular laboratory methods and epidemiology. Together, Drs. Zakai and Durda will provide individualized assistance to project directors and innovative workshops utilizing a flipped classroom approach. Services will also be offered to Pilot Grant award recipients who will be supported by institutionally committed funds, to other investigators in the Center's Pipeline development program of potential future Project Directors, and to the UVM research community using a fee-for-service model. Over time the Core will become sustainable, serving the needs of the cardiovascular and neurovascular research community at the University of Vermont.