Neuroimaging Core (NI)

神经成像核心(NI)提供使用最先进的神经成像设备和方法的途径。 Cobre基金将支持一名生物工程师(与BSTIM Core共享)，负责监督技术方面 并开发将图像采集与刺激和康复技术相结合的新方法； 时间图像技术员，将为复杂的分析和解释提供培训和帮助 测量；脑电技术人员的部分工作，他将指导高密度脑电技术 并协助数据分析；以及为将在以下方面提供指导和培训的高级教员做出奉献努力 人类和动物研究的严谨性、重复性和解释力以及方法的发展。特定的 目标是：(1)为Cobre调查人员提供使用现代神经成像工具进行调查的交钥匙途径 与中风康复相关的脑形态、连通性、代谢和功能的变化；(2)发展 观察神经对不同干预措施的详细反应(包括短期和长期)的创新工具；3) 生成高质量、可重现的定量数据，以帮助识别神经成像“生物标记物”，从而 成为形成大型多系统量化数据集以纳入Cobre综合数据的领导者 多学科数据库(CMD)以及国家和国际数据共享努力；以及4)指导和 培训Cobre调查人员获取和分析复杂的神经成像数据，以便他们能够 开发固有的可塑性，开发和翻译基于经验的新机制 干预方法。在实现这些目标方面不断取得进展，将使国家创新中心成为主要的资源 在将神经成像纳入中风康复研究方面，MUSC以及全国和 在国际上。NI核心将促进研究人员获得结构和功能成像方法，如 如血氧水平依赖(BOLD)磁共振波谱(MRS)，动脉自旋标记(ASL)， 和高密度脑电(EEG)，使他们能够提出重要的研究问题，如 组织体积与卒中适应性可塑性、卒中病理、基础 新陈代谢，局部细胞复杂性的估计，局部脑刺激的局部反应以及 相应的功能反应。国家创新中心的多模式、跨学科、综合性的性质鼓励 协同创新。在扫描仪内使用经颅磁刺激的能力(即，交错 TMS/fMRI)使MUSC成为调查人员可以立即和更长时间直接检查的极少数地方之一- 脑刺激干预对脑活动和血流动力学的长期影响及其原因探讨 在大脑网络的皮质和皮质下节点的诱导活动的性质。此外，7T小动物 扫描和双光子显微镜系统提供了灵敏的平移工具来研究机制 基础康复和皮质刺激增强动物神经可塑性和卒中康复 模特们。

The Neuroimaging Core (NI) provides access to state-of-the art neuroimaging facilities and methodologies. COBRE funds will support a Bioengineer (shared with the BSTIM Core) who will oversee the technical aspects and develop new methods to interface image acquisition with stimulation and rehabilitation techniques; a full- time Image Technician who will provide training and assistance for analysis and interpretation of complex measurements; partial effort of an EEG Technician who will provide guidance in techniques for high density EEG and assist with data analyses; and dedicated effort for senior faculty who will provide mentoring and training in rigor, reproducibility and interpretation as well as methods development for human and animal studies. Specific aims are to: (1) Provide COBRE investigators with turnkey access to modern neuroimaging tools to investigate stroke-recovery related changes in brain morphology, connectivity, metabolism and function; (2) Develop innovative tools to observe the detailed neural response (both short- and long-term) to diverse interventions; 3) Generate high quality, reproducible, quantitative data to help identify neuroimaging “biomarkers” and thereby become a leader in forming large multi-system quantitative data sets for inclusion in the COBRE Comprehensive Multidisciplinary Database (CMD) as well as national and international data sharing efforts; and 4) Mentor and train COBRE investigators in the acquisition and analysis of complex neuroimaging data so they can investigate and exploit inherent plasticity and develop and translate novel mechanism-based, experience-dependent interventional methods. Continuous progress toward these aims will establish the NI Core as a premier resource in the integration of neuroimaging into stroke rehabilitation studies at MUSC, as well as nationally and internationally. The NI Core will facilitate investigators’ access to structural and functional imaging methods such as blood oxygen level dependent (BOLD) magnetic resonance spectroscopy (MRS), arterial spin labeling (ASL), and high density electroencephalography (EEG), enabling them to ask important research questions such as tissue volume associated with the stroke and adaptive plasticity, stroke pathology, correlates of basal metabolism, local estimates of cellular complexity, regional responses to localized brain stimulation and corresponding functional responses. The NI Core’s multimodal, cross-disciplinary, integrative nature encourages collaborative innovation. The ability to use transcranial magnetic stimulation within the scanner (i.e., interleaved TMS/fMRI) makes MUSC one of very few places where investigators can directly examine immediate and longer- term effects of brain stimulation interventions on brain activity and hemodynamics, and investigate the causal nature of induced activity in cortical and subcortical nodes of a brain network. In addition, 7T small animal scanning and two-photon microscopy systems provide sensitive translational tools to investigate mechanisms underlying rehabilitation and cortical stimulation enhancement of neural plasticity and stroke recovery in animal models.