Clinical Core

西奈山ADRC（佐野）：临床核心（核心B）-研究总结 临床核心提供认知障碍患者的临床和生物学特征方面的专业知识。 丧失和痴呆以及识别未受损老年人的能力。这些专业知识被用来招聘 并维持一组不同年龄、临床表现、教育程度、种族和 种族这个特征鲜明的队列支持广泛的痴呆和认知研究 在ISMMS、西奈山卫生系统（MSHS）和国家倡议（如 国家阿尔茨海默病协调中心（NACC），全基因组阿尔茨海默病研究（GWAS），阿尔茨海默病 疾病合作研究（ADCS）和阿尔茨海默病神经影像学倡议（ADNI）。的作用 核心是开发和实施临床程序，并收集高标准的生物标志物 老年人的特征，包括正常、前驱和受影响受试者的各个阶段 “准备好研究”的人群临床核心为研究提供受试者、组织和数据， 与疾病的临床表现、病程、治疗反应相关的临床研究专业知识， 和招聘的可行性，以帮助指导设计和实施研究中心内和广泛 在MSHS中。在中心内，临床核心提供了研究的基本要素：受试者和 参与生物标志物和遗传学核心的临床表征; 脑捐赠和其他标本分发给神经病理学核心;临床和教育 与ORE和REC核心的项目和学员互动的专业知识。核心创新在于 开发评估工具;将评估应用于新人群;调整新成像 将技术应用于临床“真实的世界”;以及对新的、研究不足的或重新利用的化合物进行临床试验。 该中心在向痴呆症研究中代表性不足的群体进行外展方面有着丰富而成功的历史， 本申请书已加入条文，以延续这项规定。该中心积极培训年轻的调查人员， 支持来自其他领域的研究人员，他们希望在他们的临床人群中研究认知。

Mount Sinai ADRC (Sano): Clinical Core (Core B) – Research Summary The Clinical Core provides expertise in the clinical and biological characterization of individuals with cognitive loss and dementia and the ability to identify non-impaired older individuals. This expertise is utilized to recruit and maintain a cohort of participants of varying ages, clinical presentations, educational attainment, races and ethnicities. This well-characterized cohort supports a broad array of dementia and cognitive research conducted within the ISMMS, the Mount Sinai Health System (MSHS,) and national initiatives such as the National Alzheimer's Coordinating Center (NACC), the Genome Wide Alzheimer's Study (GWAS), Alzheimer's Disease Cooperative Studies (ADCS), and the Alzheimer's Disease Neuroimaging Initiative (ADNI). The role of the core is to develop and implement clinical procedures and collect biomarkers for the high standard characterization of elders spanning the spectrum of normal, prodromal, and various stages of affected subjects into “research-ready” cohorts. The Clinical Core provides subjects, tissue, and data for studies as well as clinical research expertise related to clinical manifestations of disease, disease course, treatment responses, and recruitment feasibility to help guide the design and implementation of studies within the Center and broadly within the MSHS. Within the Center, the Clinical Core provides the essentials for research: the subjects and their clinical characterization to participate in the Biomarker and Genetics Cores; the clinical characterization of brain donations and other specimens disseminated to the Neuropathology Core; clinical and educational expertise to interact with the projects and trainees of the ORE and REC cores. The Core innovates in the development of assessment tools; application of assessments to new populations; adaptation of new imaging technologies into the clinical `real world'; and clinical trials of novel, under-studied or repurposed compounds. The Core has a rich and successful history of outreach to groups underrepresented in dementia research and provisions to continue this are built into this application. The Core is active in training young investigators and supporting investigators from other fields who wish to study cognition in their clinical populations.