The National Center for Interventional Biophotonic Technologies (NCIBT)

项目总结--总体 国家介入生物光子技术中心(NCIBT)的长期目标是促进 通过推进一种新的程序内、图像引导的决策模式，促进公共卫生。该中心的 战略是推进光学光谱学和成像技术，开发提供成像的手段 结果对当时的医生来说，在形式上和语境上都会起到最大的指导作用 决定，并通过让尽可能多的科学家和医生参与进来，最大限度地发挥这项工作的影响 开发和使用这些技术。最初，该中心将促进以下技术进步 介入性荧光寿命成像(IFLIM)和干涉漫反射光谱(IDOS)和 将其转化为临床应用。一个不限成员名额的程序内平台将纳入它们，并最终， 互补的光学成像技术。具体地说，NCIBT将(1)推进可伸缩光学成像 从智能光学系统设计的角度构建的技术，用于表征 最有效的方式；(2)开发一个实际结合这些技术的程序内平台 并将生成的成像数据、手术细节和患者特定信息整合到AI- 基于决策算法，实时指导治疗决策，以及(3)传播这些技术 研究机构和医疗中心的进步。这个项目的意义来自于它的 在人工智能指导的仪器设计整体方法的催化下，其光学技术有快速发展的潜力 成像技术和平台及其与管理人类最常见的疾病--癌症的相关性， 中风、心脏病、创伤、感染和退化性疾病。NCIBT将确保在全国范围内影响 通过创建和扩展协作研究和服务网络来实现这些技术进步 在全国范围内广泛分布的项目，并实施全面的培训和传播方案。 年度讲习班、国家会议、特别课程和加州大学戴维斯分校的实际培训课程， 演讲和出版物将对NCIBT技术的潜在用户进行教育、培训、装备和多样化。 弥合工程与医学、技术开发与临床应用之间的鸿沟 将确保所需技术的开发和临床应用，以提高国民的健康水平。

PROJECT SUMMARY – Overall The long-term goal of the National Center for Interventional Biophotonic Technologies (NCIBT) is to promote public health by advancing a new paradigm for intraprocedural, image-guided decision making. The Center's strategy is to advance optical spectroscopy and imaging technologies, to develop means of providing imaging results to medical practitioners at the time, in the form, and within the context they will be most useful in guiding decisions, and to maximize the impact of this work by involving as many scientists and physicians as possible in developing and using these technologies. Initially, the Center will promote technological advancements of interventional fluorescence lifetime imaging (iFLIM) and interferometric diffuse optical spectroscopy (iDOS) and their translation into clinical use. An open-ended intraprocedural platform will incorporate them and, eventually, complementary optical imaging technologies. Specifically, NCIBT will (1) advance scalable optical imaging technology, built from the perspective of intelligent optical system design, to characterize tissue properties in the most effective manner; (2) develop an intraprocedural platform that physically incorporates these technologies and integrates the resulting imaging data, details of the procedure, and patient-specific information within AI- based decision algorithms that guide, in real-time, therapeutic decisions, and (3) disseminate these technological advancements to research institutions and medical centers. The significance of this project derives from its potential for rapid advancement, catalyzed by an AI-directed holistic approach to instrument design, of its optical imaging technologies and platform and their relevance to managing humanity's most common afflictions - cancer, stroke, heart disease, trauma, infection, and degenerative diseases. NCIBT will ensure the national impact of these technological advancements by creating and expanding a network of collaborative research and service projects broadly distributed nationwide and implementing a comprehensive training and dissemination program. Annual workshops, hand-on training sessions at national meetings, in special courses and at UC Davis, presentations and publications will educate, train, equip and diversify potential users of NCIBT technology. Bridging gaps between engineering and medicine and between technology development and clinical application will ensure that the needed technologies are developed and applied clinically to improve the nation's health.