Adipose Tissue Core

摘要/摘要- ATC 脂肪组织由广泛的细胞类型（例如脂肪细胞、成纤维细胞、干细胞、成纤维细胞 细胞，白细胞），控制脂肪组织储存营养物质和调节 新陈代谢.肥胖导致所有AT细胞类型的定性和定量改变， 取决于在体内的位置、代谢状态和性别。脂肪的基本作用 肥胖症的组织扩张需要研究人员获得试剂、技术和 用于评估脂肪细胞大小、脂肪组织炎性张力、谱系关系的测定 在临床前小鼠模型以及人类中， 样品脂肪组织的高脂含量和组织加工极限的挑战 在研究中广泛应用严格的脂肪组织评估， 肥胖研究领域的许多空白。建立脂肪组织核心（ATC）， 解决这些差距已经帮助一系列研究人员将脂肪组织 在概念模型和实验中进行评估。空管的目标是：（1） 就严格的实验方法提供咨询和培训， 脂肪细胞通过旁分泌和内分泌与其他类型的细胞发育、发挥功能并相互作用。 机制等(2)提供获得所需专业技术的机会， 评估脂肪组织生物学。(3)为研究者提供组织细胞数据库， 最先进的分析，组织学和其他设备，以及动物模型的研究 脂肪组织功能(4)开发和实施有利于MNORC的新技术 对脂肪组织生物学感兴趣的研究人员。将向符合条件的研究者提供服务 通过这些目标，在脂肪组织生物学专家的监督下， 评估脂肪组织功能的现有技术方法的可重复应用， 小鼠和人类样品。

Abstract/Summary - ATC Adipose tissue is composed of a wide range of cell types (e.g. adipocytes, fibroblasts, stem cells, leukocytes) that control the ability of adipose tissue to store nutrients and regulate metabolism. Obesity leads to qualitative and quantitative alterations in all AT cell types that depends on location in the body, metabolic state, and sex. The fundamental role of adipose tissue expansion in obesity requires investigators access to the reagents, techniques, and assays to evaluate adipocyte size, adipose tissue inflammatory tone, lineage relationships between cell types, and metabolic function in pre-clinical mouse models as well as human samples. The high lipid content of adipose tissue and the challenges in tissue processing limit the broad application of rigorous adipose tissue assessments in research studies leading to many gaps in the field of obesity research. The Adipose Tissue Core (ATC) was established to address these gaps has assisted a range of investigators incorporate adipose tissue assessments in their conceptual models and experiments. The aims of the ATC are (1) To provide consultation and training on rigorous experimental approaches to investigate how adipocytes develop, function, and interact with other cell types through paracrine and endocrine mechanisms. (2) To provide access to the specialized techniques required to rigorously evaluate adipose tissue biology. (3) To provide investigators with tissues, cells, databases, state-of-the-art assays, histological and other equipment, and animal models for the study of adipose tissue function. (4) To develop and implement new technologies beneficial to MNORC investigators interested in adipose tissue biology. Services will be offered to investigators in line with these aims with oversight from experts in adipose tissue biology to ensure rigorous and reproducible application of state of the art approaches to assess adipose tissue function in mouse and human samples.