The SKyRoCKeT Study: Surface-Knit and Reformulate CADENCE-Kids for Translation.

7.项目摘要/摘要 体力活动(PA)与儿童的许多短期和长期健康结果有关， 青少年和年轻人(统称为年轻人)。具体地说，剂量-反应关系相反 存在于中度到重度PA(MVPA)和心脏代谢危险因素之间。准确量化 年轻人每天的MVPA对于有效的监测、研究、临床和公共卫生是必不可少的 申请。然而，强度在能量消耗(即氧气消耗)方面的技术表达 或以代谢当量或蛋氨酸表示的代谢成本)和/或年龄预测心率的百分比 除了那些受过人类生理学训练的人之外，所有人都可能无法理解最大值。一个更实际的可访问性 然而，仍然需要客观的衡量标准来跟踪和影响年轻人的健康PA水平。 这项飞涨的研究(表面编织和重新制定韵律-儿童翻译)将建立在 R21 Cadence-Kids研究并招募了360名6-20岁年轻人的性别和年龄平衡样本 年龄到：1)创新的表面-通过连续、无偏见地按年龄编织年龄维度，以及 无人工跳跃的生理相干年龄-节奏-对数(MET)柔性表面方法 在年龄范围之间，并提高了节奏强度阈值估计的精确度。这个单一的表面 将在不同年龄之间连贯过渡，借用不同年龄段的信息，并以数据为驱动；2)重新制定 节奏-通过提供颗粒状的、特定于年龄的节奏强度阈值，计算出增强的节奏-儿童 MVPA的精确度。将使用与R21资助的飞行员类似的跑步机方案客观地收集数据 学习，用渐进的更快的步伐。如果可能，现在还将为每个人包括一场完整的跑步比赛。 我们将同时收集节奏与直接观察以及多种当代可穿戴设备 技术。收集心肺健康和习惯性PA数据，我们将开发额外的、创新的 通过基于实验室的摄氧量指标(%VO2Peak，%VO2R)来预测相对强度的算法， 心率(%HRR，%HRmax)和感觉到的劳累等级，以便于计算单独校准的 适用于自由生活或习惯性PA生活条件的阈值。我们还将调查其他 不同性别和体重指数标准差分数的体表和节奏强度阈值的差异。 将探索高度和/或腿长特定(超)曲面作为年龄的更精确的替代方案 3)通过向户外越野漫步转化，推动科学创新向前发展。我们 假设跑步机设置的节奏强度阈值将可靠地转化并引发可预测的 户外地面行走时的代谢成本是自由生活步行行为的象征。 这项突飞猛进的研究是创新的关键一步，旨在提供连贯、可解释、客观监测的 基于步骤的强度度量，广泛用于为国家PA指南、干预、评估、 分析，以学校为基础的健康教育课程和方案，以及面向年轻人的公共卫生信息。

7. Project Summary/Abstract Physical activity (PA) is associated with a number of short- and long-term health outcomes in children, adolescents, and young adults (collectively, young people). In particular, an inverse dose-response relationship exists between moderate-to-vigorous PA (MVPA) and cardio-metabolic risk factors. Accurately quantifying young people’s daily MVPA is essential for effective surveillance, research, clinical, and public health applications. Yet, technical expressions of intensity in terms of energy expenditure (i.e., oxygen consumption or metabolic cost expressed in metabolic equivalents or METs) and/or percent of age-predicted heart rate maximum may be uninterpretable to all but those trained in human physiology. A more practically accessible yet still objective metric is needed to track and influence young people’s healthful levels of PA. The SKyRoCKeT Study (Surface-Knit and Reformulate CADENCE-Kids for Translation) will build on the R21 CADENCE-Kids study and recruit a sex- and age-balanced sample of 360 young people 6-20 years of age to: 1) Innovatively surface-‘knit’ the age dimension through a continuous, unbiased-by-age, and physiologically-coherent age-cadence-log(MET) flexible surface approach without artificially-generated jumps between age ranges and with enhanced precision of cadence-intensity threshold estimates. This single surface will coherently transition between ages, borrow inter-age information, and be data-driven; 2) Reformulate CADENCE-Kids by providing granular, age-specific cadence-intensity thresholds, calculated with enhanced precision for MVPA. Data will be objectively collected using a similar treadmill protocol to the R21-funded pilot study, with incrementally faster paces. A full running bout will now also be included for everyone when possible. We will concurrently collect cadence with direct observation as well as with multiple contemporary wearable technologies. Collecting cardio-respiratory fitness and habitual PA data, we will develop additional, innovative algorithms to predict relative intensity defined by lab-based indicators of oxygen uptake (%VO2peak, %VO2R), heart rate (%HRR, %HRmax), and rating of perceived exertion to facilitate computation of individually calibrated thresholds applicable to the free-living or habitual PA living condition. We will also investigate additional differences in surfaces and cadence-intensity thresholds by sex and body mass index standard deviation scores. Height- and/or leg-length-specific (hyper)surfaces will be explored as more precise alternatives to the age dimension; and 3) Propel science forward innovatively through translation to outdoor over-ground walking. We hypothesize that treadmill-set cadence-intensity thresholds will reliably translate and allow eliciting predictable metabolic costs during outdoor over-ground walking emblematic of free-living ambulatory behaviors. The SKyRoCKeT Study is an innovative critical step to provide coherent, interpretable, objectively monitored step-based intensity metrics of widespread use to inform national PA guidelines, interventions, assessments, analyses, school-based health education curricula and programs, and public health messages for young people.