District of Columbia T32 on Neurodevelopmental Disabilities Research (DC NDD T32)

项目摘要/摘要 我们T32培训计划的主要目标是培养专注于研究的医学博士和博士后研究员 关于神经发育障碍(NDDS)。该计划，哥伦比亚特区NDD T32，与 并完全融入我们哥伦比亚特区智力和发育障碍研究中心 (DC-IDDRC)。该计划的基本原理如下：1)神经发育障碍对 美国人口的百分比，10%的家庭与患有新城疫的人生活在一起，因此这些 条件在我们的社会中是一个巨大的经济和情感负担；2) NDD的范围从遗传到后天的侮辱，需要跨学科的神经科学方法来定义 疾病的根本原因和机制；以及3)在 各种神经发育障碍，提示机制重叠。我们的实习生和导师使用 尖端技术，包括遗传、细胞/分子、生理、功能/行为和 结构/动态成像，以从事基础和平移NDD研究项目。多学科培训 根据参加培训的各种培训机会和核心设施，强调 机构。国立儿童医院(CNH)特别适合领导这一计划，其基础是：1) 在基础、转化和临床研究方面的优势，以及在NDD所有拟议领域的指导能力 研究；2)大量机构资源，用于研究和培训非国家发展方案；3)建立、强大 与所有参与机构的合作；4)它在DC-IDDRC和许多NIH奖项中的领导作用 重点关注导致NDD的条件。来自CNH、乔治·华盛顿、霍华德和乔治敦大学的30位导师 大学将参与该计划，以帮助发展和支持受训人员的职业生涯，包括 提交一份K奖申请。我们要求为3名博士后研究员/年提供资金，他们参加了一个3- 一年计划。受训人员将获得：1)具体和综合的非正规发展方案培训和2)正式和实用的培训 培训独立所需的基本和基本技能，重点是研究方法、统计、 以及严谨和可重复性。培训部分包括核心课程，该课程包括：1)主题 专业技能；2)研究和量化技能；3)沟通和写作技能。此外，受训人员将 有定制和体验式组件，以深化他们的培训。其中包括交叉训练轮换。 对于实习生(例如，临床前研究人员在诊所轮流工作，反之亦然)；定期与 世界知名的NDDS领域的领导者和作家(Mark Batshaw，MD)；我们还提供实习生 有机会参加一些活动，这些活动对于拓宽他们的视野，了解如何开展 通过与社区互动进行研究，他们的目标是在实验室或诊所以外的不同场所提供帮助， 这将加强关系并促进对NDD社区的宣传。

Project Summary/Abstract The main objective of our T32 Training Program is to train MD and PhD post-doctoral fellows in research focused on Neurodevelopmental Disabilities (NDDs). This program, the District of Columbia NDD T32, is associated with and fully integrated into our District of Columbia Intellectual and Developmental Disabilities Research Center (DC-IDDRC). The rationale for this program is as follows: 1) Neurodevelopmental disabilities affect a significant percentage of the US population, and 10% of households live with an individual with an NDD, therefore these conditions represent a substantial financial and emotional burden in our society; 2) The biological causes of NDDs range from genetic to acquired insults, requiring an interdisciplinary neuroscience approach to define underlying causes and mechanisms of disease; and 3) There is significant overlap of symptoms amongst the various neurodevelopmental disorders, suggesting overlapping mechanisms. Our trainees and mentors use cutting-edge techniques, including genetic, cellular/molecular, physiological, functional/behavioral, and structural/dynamic imaging to engage in basic and translational NDD research projects. Multidisciplinary training is emphasized, based on the variety of training opportunities and core facilities available at the participating institutions. Children’s National Hospital (CNH) is particularly well positioned to lead this program, based on: 1) Strengths in basic, translational and clinical research, and in mentorship in all the proposed areas of NDD research; 2) Substantial institutional resources for research and training in NDDs; 3) Established, strong collaborations with all participating institutions; and 4) Its leading role in the DC-IDDRC and in many NIH awards focusing on conditions causing NDDs. Thirty mentors from CNH, George Washington, Howard and Georgetown Universities will be involved in the program to help develop and support careers of the trainees, including submission of a K Award application. We request funding for 3 postdoctoral fellows/year who participate in a 3- year program. The trainees will obtain: 1) specific and integrated training in NDDs and 2) formal and practical training in basic and essential skills required for independence, with a focus on research methodology, statistics, and rigor and reproducibility. The training components include a core curriculum consisting of: 1) Subject matter expertise; 2) Research and quantitative skills, and 3) Communication and writing skills. In addition, trainees will have customized and experiential components to deepen their training. These include a cross-training rotation for trainees (e.g., preclinical researchers rotate in the clinic and vice versa); a regular discussion group with a world-renowned leader and author in the field of NDDs (Mark Batshaw, MD); and we also offer trainees opportunities to participate in activities that are critical for broadening their perspective on how to conduct research by interacting with the community they are aiming to help in different venues beyond the lab or clinic, which will enhance relationships and promote advocacy for the NDD community.