UTMB OAIC Clinical Research Resource Core 2 (CRRC2)

项目总结/摘要（CRRC 2） UTMB OAIC临床研究资源核心（CRRC 2）是支持临床研究的主要资源。 研究，包括受试者招募、跟踪和保留活动以及研究者培训。新 该核心将支持关于功能丧失和恢复的基本机制的研究; 开发和测试新的治疗方法;社区中身体功能和残疾的轨迹- 居住和住院的老年人;以及务实的，以病人为中心的疾病康复研究。所有 CRRC 2活动将支持更广泛的OAIC主题：将功能丧失和获得的途径转化为 干预措施，以改善不同老年人群的功能恢复。 CRRC 2的具体目标是： 1.支持与OAIC主题相关的临床研究。 2.协调招募、保留和研究程序方面的培训。 3.开发新的方法，以改善临床研究招募，保留和多样性。 CRRC 2在当前周期内支持了健康老年人和老年人的转化研究。 包括31个OAIC项目和43个外部项目。在肌肉生物学，新陈代谢， 营养、锻炼和行为干预在发展基础设施方面发挥了重要作用， 支持在老年人群中的基本发现的翻译，发展ACE单位功能 实验室，并参与大型多中心临床试验。 展望未来，CRRC 2将继续为支持项目招募、跟踪和留住不同的老年人， 包括OAIC网络多地点临床试验;提供标准化的健康筛查，体检， 功能、营养和身体成分评估、运动测试和训练，以及肌肉和 脂肪组织活检;监测依从性和安全性;培训研究者;支持技术的使用， 临床试验;改进方法以提高保留率和干预保真度;并制定最佳实践 在临床研究中招募不同的西班牙裔参与者。CRRC 2将继续加强OAIC 临床研究质量，效率，生产力，并为学者和 其他调查员。

PROJECT SUMMARY/ABSTRACT (CRRC2) The UTMB OAIC Clinical Research Resource Core (CRRC2) is the primary resource to support clinical research, including subject recruitment, tracking and retention activities, and investigators’ training. In the new cycle, the core will support research studies on the mechanisms underlying function loss and recovery; development and testing of novel treatments; trajectories of physical function and disability in community- dwelling and hospitalized older adults; and pragmatic, patient-centered studies on recovery from illness. All CRRC2 activities will support the broader OAIC theme: Translate pathways of function loss and gain into interventions to improve functional recovery in diverse geriatric populations. The Specific Aims of the CRRC2 are: 1. Support clinical research relevant to the OAIC theme. 2. Coordinate training in recruitment, retention, and study procedures. 3. Develop novel methods to improve clinical study recruitment, retention and diversity. The CRRC2 has supported over the current cycle translational research in healthy older adults and geriatric patients, including 31 OAIC projects and 43 external projects. Core expertise in muscle biology, metabolism, nutrition, exercise, and behavioral interventions has been instrumental in developing the infrastructure to support translation of basic discoveries in geriatric populations, developing the ACE Unit Functional Laboratory, and participating in large multisite clinical trials. Going forward the CRRC2 will continue to recruit, track and retain diverse older adults for supported projects, including OAIC Network multisite clinical trials; provide standardized health screenings, physical exams, functional, nutritional and body composition assessments, exercise testing and training, and muscle and adipose tissue biopsies; monitor compliance and safety; train investigators; support use of technology in clinical trials; improve methodologies to enhance retention and intervention fidelity; and develop best practices to recruit diverse Hispanic participants in clinical studies. The CRRC2 will continue to enhance the OAIC clinical research quality, efficiency, productivity, and provide developmental opportunities for scholars and other investigators.