Weill Cornell Medicine - Rutgers New Jersey Medical School Clinical Trials Unit

项目摘要 威尔康奈尔医学-罗格斯新泽西医学院临床试验单位（WCM-NJMS CTU）将 进行国家过敏和传染病研究所（NIAID）赞助的艾滋病毒网络研究 治疗和艾滋病毒预防;招募来自纽约市（NYC）不同社区的参与者- 纽瓦克大都市区是美国艾滋病流行的中心，居住着14%的美国人。 与艾滋病毒有关的问题;并为网络的科学议程作出贡献。该单位包括一个中央核心设施， 三个临床研究中心（CRS）。WCM-NJMS CTU为这三个组织提供中央研究支持。 CRS，包括调查和实验室监督、财务管理、质量保证、培训和 社区参与。三个CRS，WCM-Uptown，WCM-Chelsea和Rutgers NJMS，位于 纽约-纽瓦克大都市区的不同部分，并提供不同的，种族和民族多样化的服务 艾滋病毒感染者或高危人群。WCM-Uptown CRS靠近哈莱姆， 一些社区的艾滋病毒血清阳性率超过5%。WCM-Chelsea CRS位于 在切尔西，一些社区表现出纽约市最高的血清阳性率超过8%。的 罗格斯大学NJMS CRS位于纽瓦克市中心，主要为非洲裔美国人提供服务 妇女比例很高，一些社区的艾滋病毒血清阳性率超过 5%。WCM-NJMS CTU研究人员是该领域的领导者，他们正在塑造艾滋病毒治疗和艾滋病毒 预防研究议程。他们在艾滋病毒治疗策略、抗逆转录病毒治疗和 药物和治疗策略，结核病和艾滋病毒合并症，包括肝炎和神经系统疾病 并发症以及艾滋病毒预防战略，包括艾滋病毒暴露前预防（PrEP）和 综合战略。社区参与是WCM-NJMS CTU的关键优势， 和联合社区咨询委员会（CAB）以及有效传达研究结果的良好记录 回到社区。反恐组的三个社区服务中心已成功为超过1000名参加者提供了一个广泛的 在当前赠款周期内进行各种艾滋病毒治疗和预防试验，保留率和数据都很高 质量.此外，反恐组的调查人员为该项目做出了实质性的科学和领导贡献。 网络.总而言之，WCM-NJMS CTU汇集了一批不同的公认的研究人员， 领导者将与经验丰富的临床研究人员合作，进行尖端的艾滋病毒治疗， 纽约市-纽瓦克大都市地区的艾滋病毒预防研究。

PROJECT SUMMARY The Weill Cornell Medicine – Rutgers New Jersey Medical School Clinical Trials Unit (WCM-NJMS CTU) will conduct National Institute of Allergy and Infectious Diseases (NIAID)-sponsored network studies of HIV treatment and HIV prevention; enroll participants from the diverse communities of the New York City (NYC)- Newark metropolitan area, the epicenter of the HIV epidemic in the U.S. -- home to 14% of Americans living with HIV; and contribute to the networks' scientific agendas. The unit consists of a central core facility and three clinical research sites (CRS). The WCM-NJMS CTU provides central research support to the three CRSs, including investigative and laboratory oversight, financial administration, quality assurance, training, and community engagement. The three CRSs, WCM-Uptown, WCM-Chelsea, and Rutgers NJMS, are located in different parts of the NYC-Newark metropolitan area and serve distinct, racially and ethnically diverse populations of people living with or at-risk for HIV. The WCM-Uptown CRS is located close to Harlem, with some neighborhoods demonstrating HIV seroprevalence rates of over 5%. The WCM-Chelsea CRS is located in Chelsea, with some neighborhoods demonstrating the highest seroprevalence rate in NYC of over 8%. The Rutgers NJMS CRS is located in the center of Newark, serving a predominately African American population with a high proportion of women, with some neighborhoods demonstrating an HIV seroprevalence rate of over 5%. WCM-NJMS CTU investigators are leaders in the field who are shaping the HIV treatment and HIV prevention research agendas. They are highly experienced with expertise in HIV cure strategies, antiretroviral drugs and treatment strategies, tuberculosis, and HIV comordibidities, including hepatitis and neurologic complications as well as HIV prevention strategies, including HIV pre-exposure prophylaxis (PrEP) and integrated strategies. Community engagement is a key strength of the WCM-NJMS CTU with both site-specific and joint Community Advisory Boards (CABs) and a strong record of effectively communicating study results back to the community. The CTU's three CRSs have successfully enrolled over 1000 participants into a wide variety of HIV treatment and prevention trials during the current grant cycle with outstanding retention and data quality. Furthermore, CTU investigators have made substantive scientific and leadership contributions to the networks. In summary, the WCM-NJMS CTU brings together a diverse group of recognized investigator leaders who will work with an experienced clinical research staff to conduct cutting-edge HIV treatment and HIV prevention studies in the NYC-Newark metropolitan areas.