Advanced Development of Vaccines for Infectious Diseases

本项目的主要目标是支持候选产品的高级开发，用于故意释放或应对由NIAID A、B和C类优先病原体引起的传染病自然暴发后的事件后环境。该合同可支持单个疫苗组分的配制和生产，以及非人灵长类动物的稳定性试验、非临床免疫原性和有效性试验、IND支持GLP重复给药毒理学、IND提交和最终临床评价。

The primary objective of this project is to support the advanced development of candidate products for use in post-event settings following the intentional release of or in response to naturally occurring outbreaks of infectious diseases caused by NIAID Category A, B, and C Priority Pathogens. This contract may support formulation and manufacture of the individual vaccine components, as well as stability testing, nonclinical immunogenicity and efficacy testing in nonhuman primates, IND enabling GLP repeated dose toxicology, submission of an IND and eventual clinical evaluation.