PAHs: New Technologies and Emerging Health Risks

摘要-整体中心 俄勒冈州立大学超级基金研究计划(SRP)，与太平洋西北大学合作 国家实验室和其他利益相关者和合作者，寻求开发新技术以 确定在国家超级基金的许多地点发现的多环芳烃(PAHs)混合物 补救前后。我们将确定多环芳烃的新危害和毒性机制以及现实世界 多环芳烃混合物。SRP将支持三个生物医学研究项目和两个环境科学和 工程项目。我们将这些研究项目与SRP的四项任务相结合，以解决紧迫的问题 超级基金网站的挑战。管理、社区参与、化学混合物、研究 经验和培训以及数据管理和分析核心为研究项目提供支持。这 该提案建立在我们在前一批赠款期间取得的成功的基础上。在未来五年，我们将致力于 创新、高影响力的研究目标。例如，我们建议(1)发展第一个泛化 测量多环芳烃进出超级基金地点的移动的技术，(2)测量外部暴露 为超级基金站点附近的个人提供PAHs，并确定他们的风险敞口如何随 定位；(3)预测生物和非生物过程中多环芳烃的二次转化产物 超级基金站点的补救，(4)使用斑马鱼预测复杂的多环芳烃混合物的毒性，(5)链接 在强大的人类体外呼吸模型的帮助下，多环芳烃暴露于健康结果，以及(6) 阐明毒性系统中多环芳烃敏感性的代谢和物理化学控制。核心将(1) 指导SRP的活动并将我们的调查结果传播给利益攸关方(行政)，(2)与 受多环芳烃暴露影响的社区，以解决关切并降低风险(社区参与)； 为下一代环境健康科学家提供密集的多学科培训 (RETCC)，(4)提供数据管理和分析支持(DMAC)，以及(5)应用最先进的技术 环境和环境中发现的多环芳烃和多环芳烃混合物的化学仪器和测量方法 生物基质。通过实现这些目标，我们将推进科学的前沿，也将改善 受影响社区的生活质量。

SUMMARY – OVERALL CENTER The Oregon State University Superfund Research Program (SRP), in partnership with Pacific Northwest National Laboratories and other stakeholders and collaborators, seeks to develop new technologies to identify the polycyclic aromatic hydrocarbon (PAHs) mixtures found at many of the nation's Superfund sites before and after remediation. We will identify novel hazard and toxicity mechanisms for PAHs and real-world PAH mixtures. The SRP will support three biomedical research projects and two environmental science and engineering projects. We aligned these research projects with the four SRP mandates to address pressing challenges at Superfund sites. The Administrative, Community Engagement, Chemical Mixtures, Research Experience and Training, and Data Management and Analysis cores support the research projects. This proposal builds on our successes during the previous grant period. Over the next five years, we will pursue innovative, high-impact research goals. For example, we propose to (1) develop the first generalizable technology to measure the movement of PAHs to and from Superfund sites, (2) measure external exposures to PAHs for individuals near Superfund sites and determine how their exposures vary as a function of location, (3) predict the secondary transformation products of PAHs that will form during biotic and abiotic remediation at Superfund sites, (4) predict the toxicity of complex PAH mixtures using zebrafish, (5) link PAH exposure to health outcomes with the aid of a powerful human in vitro respiratory model, and (6) elucidate metabolic and physicochemical control of PAH susceptibility in toxicity systems. The cores will (1) direct the activities of the SRP and disseminate our findings to stakeholders (Administrative), (2) work with communities impacted by PAH exposure to address concerns and reduce risk (Community Engagement); (3) provide intensive multi-disciplinary training for the next generation of Environmental Health Scientists (RETCC), (4) provide data management and analysis support (DMAC), and (5) apply state-of- the-art chemistry instrumentation and approaches to measure PAHs and PAH mixtures found in environmental and biological matrices. By accomplishing these goals, we will advance the frontiers of science and also improve the quality of life for impacted communities.