Wake Forest NCORP Research Base

维克森林NCORP癌症中心研究基地（WF NCORP RB）的总体目标是提高 通过制定、实施和成功完成癌症治疗计划， 创新和可行的癌症控制和癌症护理提供（CCDR）临床研究。近 二十年来，作为CCOP和现在的NCORP研究基地，维克森林一直专注于 癌症控制和CCDR研究，并强调有效的操作过程和广泛的 与我们的NCORP社区网站和少数民族服务不足社区网站合作伙伴的互动。期间 在NCORP网络的前4年，WF NCORP RB：开展了7项癌症控制和3项CCDR研究;入组 1，140名参与WF NCORP RB研究;获得了5项额外概念和方案的批准， 将正在进行和待审审判的剩余和计划应计案件总数增加到4 420多名参与人; 33%的种族/少数民族参与者，以及68%的女性，14%的农村居民和26%的年龄 65或更大。在接下来的6年里，我们将通过以下方式建立和加强这个非常成功的平台： 实现以下具体目标：具体目标1：扩大我们的癌症控制临床研究活动 在以下领域：癌症治疗的心血管并发症;放疗和化疗引起的 神经认知毒性;以及其他癌症和治疗相关症状和相关结局 由NCI指导委员会和通常与新型新兴治疗相关的指导委员会优先考虑 范例具体目标2：阐明并干预患者、家庭、临床医生和组织因素 影响癌症护理提供，强调生存护理，非正式的癌症护理人员， 实施循证支持性护理服务。具体目标3：阐明生物学机制 潜在的癌症和治疗相关的症状和毒性在新的和创新的多学科 利用我们不断增长的血液、尿液和唾液样本生物库进行合作研究。 具体目标4：通过以癌症为重点的研究，确定和解决癌症差异的决定因素， 综合目标侧重于得不到充分服务的人口，有针对性地招募种族和族裔少数群体， 在所有维克森林NCORP研究调查中，具体目标5：培训 下一代癌症控制和CCDR研究人员通过指导和早期职业生涯的参与 教师，肿瘤学实习生，博士后研究员和WF NCORP活动的学生。我们正在进行的和 拟议的癌症控制和CCDR研究将通过提供最佳实践，继续改善肿瘤治疗 用于症状和晚期效应管理以及有效、以患者为中心、循证的癌症护理 为不同的患者群体提供服务。在下一个资助期内，WF NCORP RB将帮助加快 通过与社区的密切合作，转化癌症控制和癌症护理方面的知识 和少数民族服务不足的网站和研究，为今后的传播和实施。

The overarching goal of the Wake Forest NCORP Cancer Center Research Base (WF NCORP RB) is to improve patient well-being and the quality of cancer care by developing, implementing and successfully completing innovative and feasible Cancer Control and Cancer Care Delivery (CCDR) clinical research studies. For nearly two decades as a CCOP and now NCORP Research Base, Wake Forest has maintained an exclusive focus on Cancer Control and CCDR studies and has emphasized efficient operational processes and extensive interactions with our NCORP Community Site and Minority Underserved Community Site partners. During the first 4 years of the NCORP network, the WF NCORP RB: opened 7 Cancer Control and 3 CCDR studies; enrolled 1,140 participants on WF NCORP RB studies; obtained approval for 5 additional concepts and protocols bringing the total remaining and planned accrual for active and pending trials to over 4,420 participants; and achieved a 33% accrual rate of racial/ethnic minority participants, as well as 68% women, 14% rural residents and 26% age 65 or greater. Over the next 6 years, we will build on and strengthen this highly successful platform by accomplishing the following Specific Aims: Specific Aim 1: Extend our cancer control clinical research activities in the following areas: cardiovascular complications of cancer therapy; radiation and chemotherapy-induced neurocognitive toxicities; and additional cancer and treatment-related symptoms and related-outcomes prioritized by NCI steering committees and those commonly associated with novel emerging treatment paradigms. Specific Aim 2: Elucidate and intervene upon patient, family, clinician, and organizational factors that influence cancer care delivery, emphasizing survivorship care, informal cancer caregivers and implementation of evidence-based supportive care services. Specific Aim 3: Illuminate biological mechanisms underlying cancer and treatment-related symptoms and toxicities in new and innovative multidisciplinary collaborative studies taking advantage of our growing biobank of blood, urine and salivary fluid specimens. Specific Aim 4: Identify and address determinants of cancer disparities via disparities-focused studies, integrated aims focused on underserved populations, and targeted recruitment of racial and ethnic minority and underserved populations across all Wake Forest NCORP research investigations. Specific Aim 5: Train the next generation of Cancer Control and CCDR researchers through mentoring and involvement of early career faculty, oncology trainees, post-doctoral fellows, and students in WF NCORP activities. Our ongoing and proposed Cancer Control and CCDR studies will continue to improve oncology care by informing best practices for symptom and late effect management as well as efficient, patient-centered, evidence-based cancer care delivery for diverse patient populations. In the next funding period, the WF NCORP RB will help accelerate the translation of knowledge in cancer control and cancer care delivery through close partnership with community and minority underserved sites and studies designed for future dissemination and implementation.