Vermont Center for Cardiovascular and Brain Health

项目摘要 心血管疾病是美国死亡的第一原因，中风是第五原因。中风是 也是残疾的头号原因，它与包括小血管疾病在内的隐性神经血管疾病一起沿着 血管性认知障碍和痴呆症（VCID）。每年有80万美国人 72万美国人患有心肌梗塞。到2020年将有7500万痴呆症患者 到2030年和1.31亿到2050年。心血管疾病和中风的直接年度成本为3180亿美元， 痴呆症2770亿美元美国心脏协会在2017年发布了一份总统咨询报告， 心血管健康对大脑健康和认知功能的核心作用。大部分VCID是由增加驱动的 在隐蔽性中风和脑小血管疾病，研究领域的专业知识， 应用程序.为了解决这些问题，佛蒙特大学（UVM）心血管和大脑中心 卫生部（VCCBH）将利用NIH的资金和机构承诺， 跨职业阶段的研究人员，以确定原因，并建议最佳治疗心血管和 神经血管疾病，包括中风和VCID。我们选择了四个初级教师（项目主任， PD），从三个部门和两个UVM学院，通过严格的选拔过程。VCCBH将 支持PD的过渡到独立使用战略指导倡议（SMI），教师发展 计划（FDP），以及两个新的核心设施的援助和教育。SMI将雇用 多学科导师团队，包括同行导师。FDP将包括几个教育项目 通过为期两天的年度研究研讨会和有影响力的试点资助计划（由 机构承诺），将提供20万美元的四个跨学科的研究小组的初级教师。 我们将建立两个新的核心设施：研究设计和分子流行病学，以及定制 生理学和成像。将从现有的19名项目主任中培养一批新的项目主任。 候选人和五个新的初级教师，谁将与承诺的机构支持招聘。顶点 该中心将包括持续的质量评估，清晰的沟通和对多样性的承诺。由 完成第一阶段的资助后，该中心将走上一条通往卓越研究可持续发展的强大道路。

PROJECT SUMMARY Cardiovascular disease is the #1 cause of mortality in the United States and stroke is the #5 cause. Stroke is also the #1 cause of disability, and it, along with covert neurovascular disease including small vessel disease of the brain, leads to Vascular Cognitive Impairment and Dementia (VCID). Each year 800,000 Americans have a stroke and 720,000 Americans have myocardial infarction. There will be 75 million people with dementia by 2030 and 131 million by 2050. Direct annual costs of cardiovascular disease and stroke are $318 billion and dementia $277 billion. The American Heart Association issued a Presidential Advisory in 2017 highlighting the central role of cardiovascular health to brain health and cognitive function. Much of VCID is driven by increases in covert stroke and small vessel disease of the brain, research areas of expertise for the PIs of this application. To address these issues, this University of Vermont (UVM) Center on Cardiovascular and Brain Health (VCCBH) will leverage NIH funding and institutional commitment to convene multidisciplinary researchers across career stages to determine causes and suggest optimal treatments for cardiovascular and neurovascular disease, including stroke and VCID. We have selected four junior faculty (Project Directors, PDs), from three departments and two UVM colleges, through a rigorous selection process. The VCCBH will support the PDs' transition to independence using a Strategic Mentoring Initiative (SMI), Faculty Development Program (FDP), and assistance and education from two new Core facilities. The SMI will employ multidisciplinary Mentor Teams, including Peer Mentors. The FDP will comprise several educational programs highlighted by an annual 2-Day Research Symposium, and an impactful Pilot Grant program (supported by institutional commitments) that will provide $200,000 to four interdisciplinary research teams of junior faculty. We will establish two new Core facilities: Study Design and Molecular Epidemiology, and Customized Physiology and Imaging. A pipeline of new project directors will be developed from a pool of 19 current candidates and five new junior faculty, who will be recruited with committed institutional support. Capstones of the Center will include continual quality evaluation, clear communication and commitment to diversity. By the completion of Phase I of funding, the Center will be on a strong path to sustainability in research excellence.