Core B: Study Design and Molecular Epidemiology Core

项目总结 心血管疾病、中风和认知障碍/痴呆是导致死亡和残疾的主要原因， 它们源于几个共同的先例。拟建的佛蒙特州心血管和大脑中心 佛蒙特大学的健康(VCCBH)科布雷将通过合作 研究。这将由来自多个学科的不同科学家合作进行，以了解 为迎接公共卫生挑战，这些疾病的病理生物学和分子流行病学 由他们提出。Cobre Will的研究设计和分子流行病学核心(CORE B) 支持中心项目主任向独立地位发展。它将利用三十年的 佛蒙特大学临床与生化研究实验室的经验 分子流行病学实验室和一个包含约470万份来自&gt；100,000；的样本的生物库 来自许多观察性队列研究和临床试验的研究参与者。核心将装备多个- 具有开展创新研究所需技能的学科项目主管 设计和统计分析，并将他们的结果从试验台或临床研究环境转换到 人口研究的背景和背景，无论他们以前有过流行病学经验。我们的理念是 核心不仅应该提供服务，而且应该培训调查人员，使其熟练掌握所有关键 核心提供的元素。因此，核心将向项目主任提供初步和持续的正式 对研究设计和统计方法的意见(目标1)；就以下各方面向项目主任提供建议 生物样本的获取、存储和分析，包括分析性能的优化和故障排除 (目标2)；并通过将他们与国家资源联系起来，支持他们向独立过渡 使他们能够将他们的研究转化为临床环境的研究(目标3)。Core的联席董事，Dr。 Neil Zakai和Peter Durda博士以及核心生物统计学家将指导项目主任。扎凯博士是一位 血液学家和慢性病流行病学家，在多种类型的研究设计、生物统计学方面具有专业知识 处理复杂数据和实验室操作的方法，而杜尔达博士在分子方面拥有丰富的经验 实验室方法和流行病学。Zakai博士和Durda博士将共同为 项目主管和采用翻转课堂方法的创新研讨会。还将提供服务 向将得到机构承诺资金支持的获奖者进行试点，向其他调查人员提供 在该中心未来潜在项目总监的流水线发展计划中，以及UVM研究 使用按服务收费模式的社区。随着时间的推移，核心将变得可持续，服务于 佛蒙特大学心血管和神经血管研究社区。

PROJECT SUMMARY Cardiovascular disease, stroke and cognitive impairment / dementia are leading causes of death and disability, and they arise from several common antecedents. The proposed Vermont Center for Cardiovascular and Brain Health (VCCBH) COBRE at the University of Vermont will address these diseases employing collaborative research. This will be conducted by diverse scientists from multiple disciplines working together to understand the pathobiology and molecular epidemiology of these diseases in order to meet the public health challenges presented by them. The Study Design and Molecular Epidemiology Core (CORE B) of the COBRE will support the evolution of the Center's Project Directors to independent status. It will leverage three decades of experience of the Laboratory for Clinical and Biochemistry Research at the University of Vermont, a leading molecular epidemiology laboratory and home to a biorepository containing ~4.7 million samples from >100,000 research participants from many observational cohort studies and clinical trials. The core will equip the multi- disciplinary Project Directors with the skills they need to conduct their research applying innovative study designs and statistical analyses, and to translate their results from bench or clinical research settings to the population research setting and back, regardless of their prior experience in epidemiology. Our philosophy is that a Core should not only provide service but should train an investigator to be skilled in all of the key elements that the Core provides. Thus, the Core will provide Project Directors with initial and ongoing formal input on their study design and statistical approaches (Aim 1); advise Project Directors on all aspects of biosample procurement, storage, and analysis, including optimizing and troubleshooting assay performance (Aim 2); and support their transition to independence by connecting them with the resources of national studies that will allow them to translate their research to clinical settings (Aim 3). The Core co-directors, Dr. Neil Zakai and Dr. Peter Durda, along with Core biostatisticians, will guide the Project Directors. Dr. Zakai is a hematologist and chronic disease epidemiologist with expertise in many types of study designs, biostatistical approaches to complex data, and laboratory operations, while Dr. Durda has vast experience in molecular laboratory methods and epidemiology. Together, Drs. Zakai and Durda will provide individualized assistance to project directors and innovative workshops utilizing a flipped classroom approach. Services will also be offered to Pilot Grant award recipients who will be supported by institutionally committed funds, to other investigators in the Center's Pipeline development program of potential future Project Directors, and to the UVM research community using a fee-for-service model. Over time the Core will become sustainable, serving the needs of the cardiovascular and neurovascular research community at the University of Vermont.