MEDIC - MicroED Imaging Center - Admin Core

行政和管理 总结 行政核心将为拟议的多名调查员提供组织框架 项目，加州大学洛杉矶分校的MEDIC - MicroED成像中心。AC将由两名PI领导，Tamir Gonen博士 还有帕维尔·彭切克MEDIC中心的联合管理将确保资源的有效运作。 不受PI其他职责的干扰。该核心的活动将包括： 研究和技术开发的所有集团，保持通信和之间 推动生物项目，解决预算问题，组织内部月度会议 咨询委员会，每年一次外部咨询会议，最多两次培训和宣传 每年的研讨会。它还将负责编写年度进度报告，并将保持 并更新资源共享设施。该中心将受益于Gonen博士在以下方面的丰富经验： 管理冷冻EM资源和多用户设施项目。Gonen博士建立并指导了几个冷冻EM 在过去的15年里，美国各地的设施，包括最多产的cryoEM用户设施在Janelia HHMI的研究园区是世界上第一个用于cryoEM的同步加速器式设施。彭切克医生 20年成功的NIH支持的研究，包括参与多PI计划项目和加入PI 赠款。此外，Penczek博士担任UTH结构生物学成像中心主任长达12年， 一个多用户设施，支持UT医学中心的结构生物学研究，包括NMR，X射线， 晶体学和冷冻电镜，并在独立的预算下运作。在他的领导下，设施不断发展， 最终在2017年成功收购了UT资助的Krios TEM。自2017年以来，Penczek博士担任 UT中心的联合主任Gonen博士和Penczek博士将共同组建一个内部咨询委员会 由技术研究和开发项目（TRD）的精英成员组成，并选择关键的 人员的该委员会将建立并确保MEDIC的最佳操作程序， 确定合格项目的程序和标准。它还将负责决心和 技术传播讲习班的形式，并在必要时在技术合作与发展项目之间重新分配资金。 最重要的是设立外部咨询委员会。该委员会的作用将 建议项目的总体科学方向，建议传播工作和社区 参与，帮助保持其重点，并保持奉献和忠实于医疗的原始使命。的 行政核心将每年组织一次为期一天的外部咨询委员会及其成员会议 预计将准备一份报告，该报告将与项目的所有PI和关键人员以及 国家卫生研究院

ADMINISTRATION AND MANAGEMENT SUMMARY The Administrative Core (AC) will provide an organizational framework for the proposed multi-investigator project, the MEDIC – MicroED Imaging Center at UCLA. The AC will be led by the two PIs, Drs. Tamir Gonen and Pawel Penczek. The joint directorship of the MEDIC center will ensure efficient functioning of the Resource uninterrupted by other responsibilities of the PIs. The activities of this Core will include synchronization of the research and technology development of all groups, the maintenance of communications with and between Driving Biological Projects, the resolution of budgetary issues, organization of monthly meetings for an Internal Advisory Committee, a yearly meeting of an External Advisory Meeting, and up to two training and dissemination workshops per year. It will also be responsible for the preparation of the yearly Progress Report and will maintain and update the Resource Sharing facility. The center will benefit from Dr. Gonen having extensive experience in managing cryoEM resources and multi-user facility projects. Dr. Gonen established and directed several cryoEM facilities around the USA in the last 15 years, including the most prolific cryoEM user facility at the Janelia Research Campus of HHMI which was the first synchrotron-like facility for cryoEM in the world. Dr. Penczek has 20 years of successful NIH-supported research including participation in multi-PI program project and joined PI grants. In addition, for 12 years Dr. Penczek served as a Director of the UTH Structural Biology Imaging Center, a multi-user facility supporting structural biology research at UT Medical Center, including NMR, X-ray crystallography, and cryo-EM and operating under an independent budget. Under his leadership the facility grew, culminating in the successful acquisition of a UT-funded Krios TEM in 2017. Since 2017 Dr. Penczek serves as a co-director of the UT Center. Together, Drs. Gonen and Penczek will formulate an Internal Advisory Committee comprised of elite members of the Technology Research and Development projects (TRDs) and select key personnel. This committee will establish and ensure optimal operating procedures for MEDIC, access procedures and criteria for determining eligible projects. It will be also responsible for determination and the format of technology dissemination workshops and, if necessary, for reallocation of funds between TRD projects. Of utmost importance is the establishment of the External Advisory Committee. The role of this Committee will be to advise on the overall scientific direction of the project, advise on dissemination efforts and community engagement, help to maintain its focus and to stay devoted and faithful to the original mission of MEDIC. The Administrative Core will organize a yearly one-day meeting of the External Advisory Committee and its members will be expected to prepare a report that will be shared with all PIs and key personnel of the Project and with the NIH.