Extensible Open Source Zero-Footprint Web Viewer for Cancer Imaging Research

项目总结/摘要 Open Health Imaging Foundation（OHIF）Viewer及其底层库（如Cornerstone） 成为癌症研究中基于网络的成像信息学技术的标准框架， 此外，它还支持数百个开源项目，拥有数千名用户。通过OHIF，开发人员可以： 1)添加新的创新工具作为OHIF查看器的扩展; 2）使用特定的OHIF模块或库， 建立自己的定制工具; 3）使现有桌面信息学平台能够上网。支持 从桌面工具过渡到基于网络的工具，研究人员需要有良好的支持框架来建立。 目前，许多癌症研究图像查看器需要在每个用户的本地计算机上安装软件。 工作站，这是一个缺点，限制了可访问性和易于协作。目前可用的大多数网络浏览器 是专有的、封闭的系统，或者是使用传统技术的开源研究应用程序。为 癌症成像研究需要多个站点协作，因此越来越需要一个框架， 使研究人员能够远程查看图像并与同事协作。OHIF的零足迹网站- 查看器工具为最终用户提供了巨大的可用性优势，最终用户可以即时访问查看数据， 没有安装或更新任何软件的计算机。 在之前的NCI ITCR U24资助下，我们开发了OHIF框架，该框架提供了专业的- 一个免费的、开源的、基于网络的、用于癌症研究的成像环境，带有图像审查、注释 功能和用户友好的界面。OHIF查看器依赖于标准， 它可以与其他系统集成，并且可以扩展以提供自定义功能，而无需修改 核心应用此外，它的组件可以重复使用，以快速开发新的应用程序， 使癌症研究工具能够过渡到云计算。 该提案的核心目标是加强和维持OHIF平台，并扩大用户和 这项技术的贡献者基础。目前的项目有三个目标：1）扩大网络观众的癌症 成像可视化和分析功能; 2）通过创建即用型 用于本地和云托管部署的安装程序;以及3）扩展我们的支持基础架构， 癌症研究社区。对于社区支持，我们将加强我们的外展，参与和支持 促进与开发人员和最终用户合作的举措。为了便于临床翻译， 分享我们在监管合规方面的经验，我们将实施质量管理体系（QMS）， 核心OHIF框架开发，并定期向社区发布设计文档。 增强平台的功能、简化安装和丰富支持将使研究人员 更好地合作评估癌症疾病进展的性质和对治疗的反应。与 随着OHIF平台的广泛采用，这些改进的影响将是深远的。

Project Summary/Abstract The Open Health Imaging Foundation (OHIF) Viewer and its underlying libraries such as Cornerstone have become the standard framework for web-based imaging informatics technologies in cancer research and beyond, supporting hundreds of open-source projects with thousands of users. Through OHIF, developers can: 1) add new innovative tools as extensions to the OHIF Viewer; 2) use specific OHIF modules or libraries to build their own custom tools; and 3) web-enable existing desktop informatics platforms. To support the transition from desktop to web-based tools, researchers need well-supported frameworks to build upon. Currently, many cancer research image viewers require software to be installed on each user's local workstation, a drawback which limits accessibility and ease of collaboration. Most web-viewers available today are either proprietary, closed systems, or open-source research applications that use legacy technologies. For cancer imaging research that requires multi-site collaboration, there is a growing need for a framework that can enable researchers to review images and collaborate with colleagues remotely. OHIF’s zero-footprint web- viewer tools provide enormous usability benefits for end users, who gain instant access to view data across computers without any software to install or update. Under a prior NCI ITCR U24 grant, we developed the OHIF Framework, which provides a professional- grade, free, open-source web-based imaging environment for cancer research with image review, annotation functionality, and a user-friendly interface. The OHIF Viewer relies on standards, which has enabled easy integration with other systems, and it can be extended to provide custom functionality without modifying the core application. Additionally, its components can be re-used to rapidly develop new applications and help enable the transition to cloud computing for cancer research tools. The core goal of this proposal is to enhance and sustain the OHIF platform and broaden the user and contributor base of this technology. The current project has three aims: 1) extend the web-viewer’s cancer imaging visualization and analysis capabilities; 2) reduce barriers to adoption by creating ready-to-use installers for on-premises and cloud-hosted deployment; and 3) expand our support infrastructure for the cancer research community. For community support, we will enhance our outreach, engagement, and support initiatives to foster collaboration with developers and end users. In order to facilitate clinical translation and share our experience with regulatory compliance, we will implement a quality management system (QMS) for core OHIF framework development and regularly release design documentation to the community. Enhancing the platform's functionality, easing installation, and enriching support will allow researchers to better collaborate to evaluate the nature of cancer disease progression and response to treatment. With the widespread adoption of the OHIF platform to date, the impact of these improvements will be far reaching.