UNC Chemical Biology Interface Training Program

摘要 我们建议建立一个化学-生物接口(CBI)培训计划，使学员能够在 北卡罗来纳大学教堂山分校(UNC)获得必要的科学培训 现代机械信息化学生物学。这一计划借鉴了两个历史上成功的 北卡罗来纳大学的课程：北卡罗来纳大学伊谢尔曼分校的化学生物学和药物化学部 药学院，以及北卡罗来纳大学化学系的生物和有机化学部 (文理学院)。这两个单位有着强大而持续的合作传统， 共同的课程作业和一系列分享的研讨会。尽管北卡罗来纳大学有着备受推崇的科学传统， 北卡罗来纳大学校园里没有以化学为导向的NIH培训计划。拟议的计划将带来 聚集在一起的25名知名研究人员涵盖了化学生物学的广泛领域，从分析 蛋白质结构/功能的生物分析用于药物化学/药物设计。此外，还有三名有前途的小学生 教职员工将以“指导导师”的身份加入该项目，与资深同事密切合作 继续建立他们的计划。项目负责人，一名来自CBMC，一名来自能源部 化学，是具有指导和管理经验的有成就的高级教师；他们将提供 计划指导，来自内部指导委员会和一批杰出的外部 顾问。学生将从两个小学单元和北卡罗来纳大学生物/生物医学伞形机构招收。 在招收优秀和多样化的研究生方面取得了显著成功的理科项目 去校园。培训计划包括(1)为研究奠定基础的公共课程 在化学-生物界面，包括负责任地进行研究和严谨/可再现性培训， (2)每两周一次的会议，轮流召开日记俱乐部和规模较小的讨论小组，重点放在 个人学习和专业发展，(3)秋季前举行的项目务虚会 学期，提供严谨和可再现性方面的定向和早期正式培训，以及(4)由受训者组织 研讨会将成为北卡罗来纳州大学的一项重要年度活动。在化学-生物交界处的工作 随着我们对生物学的理解需要更多的分子洞察力，这一点变得越来越相关。 因此，拟议方案的活动将利用CBMC和 化学，以及在这个国际上可用的广泛的教育和研究资源 公认的机构。该计划将从以下角度为学员提供更好的教育 深度和广度，并培养训练有素的化学和生物学领域的博士学者，他们将 在学术界和工业界的生物医学科学中发挥着关键作用。

ABSTRACT We propose to establish a Chemistry–Biology Interface (CBI) Training Program that will enable trainees at the University of North Carolina at Chapel Hill (UNC) to obtain the breadth of scientific training essential for modern, mechanistically informed chemical biology. This program draws from two historically successful programs at UNC: the Division of Chemical Biology and Medicinal Chemistry (CBMC) in the UNC Eshelman School of Pharmacy, and the Biological and Organic Chemistry Divisions in the UNC Department of Chemistry (College of Arts and Sciences). These two units have a strong and continuing tradition of collaboration, common coursework, and a shared seminar series. Although UNC has a highly regarded scientific tradition, there is no chemistry-oriented NIH training program on the UNC campus. The proposed program will bring together 25 established researchers who encompass the breadth of chemical biology, ranging from analytical bioanalysis to protein structure/function to medicinal chemistry/drug design. In addition, three promising junior faculty members will join the program as “mentored mentors”, working closely with senior colleagues as they continue to establish their programs. The program leaders, one from CBMC and one from the Department of Chemistry, are accomplished senior faculty with mentoring and administrative experience; they will provide program guidance with input from an internal steering committee and a distinguished group of external advisors. Students will be recruited from the two primary units and from a UNC umbrella biological/biomedical sciences program that has shown remarkable success in recruiting outstanding and diverse graduate students to the campus. The training program includes (1) common coursework that establishes the basis for research at the chemistry–biology interface, including responsible conduct of research and rigor/reproducibility training, (2) biweekly meetings that alternate between a journal club and a smaller discussion group focused on individual learning and professional development, (3) an program retreat that will be held before the fall semester, providing orientation and early formal training in rigor and reproducibility, and (4) a trainee-organized symposium that will become a major annual event at UNC. Work at the chemistry–biology interface has become increasingly relevant as our understanding of biology has required more molecular insights. Accordingly, the activities of the proposed program will capitalize on the diverse expertise in CBMC and Chemistry, and the extensive educational and research resources that are available at this internationally recognized institution. This program will provide trainees with a superior education from the perspective of depth and breadth, and develop well-trained PhD scholars at the interface of chemistry and biology who will play a critical role in the biomedical sciences across academia and industry.