Core D: Neuropathology Core

摘要 加州大学旧金山分校ADRC神经病理学核心(Path Core)为UCSF ADRC和 加州大学旧金山分校和其他地方的神经退行性疾病研究社区。神经退行性疾病 近年来，病理学变得越来越令人兴奋和复杂，出现了以下重大进展 通过这个ADRC完成的工作。在本申请中，Path Core将继续由William博士领导 Seeley和Lea Grinberg博士共同领导。Path Core的目标是：(1)获取并存储人脑和脊椎 用于神经病理学表征和研究的脊髓组织；(2)分析标本并呈现 神经病理诊断；(3)审查组织请求并分发样本；(4)支持创新 神经病理学方法；(5)培养下一代神经学家和神经病理学家 神经退行性疾病的研究。这些目标将通过广泛的互动实现 加州大学旧金山分校ADRC的其他核心，将对该中心的整体成功产生重大影响。

ABSTRACT The UCSF ADRC Neuropathology Core (Path Core) provides vital research support to the UCSF ADRC and to the neurodegenerative disease research community at UCSF and beyond. Neurodegenerative disease pathology has become increasingly exciting and complex in recent years, with major advances arising from work accomplished through this ADRC. In this application, the Path Core will continue to be led by Dr. William Seeley and co-led by Dr. Lea Grinberg. The Path Core aims to: (1) Obtain and bank human brain and spinal cord tissue for neuropathological characterization and research; (2) Analyze specimens and render neuropathological diagnoses; (3) Review tissue requests and distribute specimens; (4) Support innovative neuropathological approaches; (5) Train the next generation of neurologists and neuropathologists conducting research on neurodegenerative disease. These goals will be accomplished through extensive interactions with the other cores of the UCSF ADRC and will have a major impact on the overall success of the center.