Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD)

摘要(总体) 这是加州大学环境健康科学核心中心的竞争续签申请 密歇根州，在我们第二个支持任期的最后一年提交。我们的中心是围绕主题组织的 对环境暴露的易感性的关键窗口作为疾病的重要决定因素，形成 密歇根生命、环境暴露和疾病中心(M-LEEAD)。生命周期，如本文件中所用 应用，指的是临床公认的发育、中年和衰老阶段，这些阶段与前 受孕期、产前、婴儿期、儿童期、青春期、育龄成人期和老年成人期。我们的中心 建立在环境健康科学研究活动和支持的坚实基础上，与22个NIEHS 赠款和项目，包括杰出的新环境健康科学家(ONE)和革命性 创新、有远见的环境健康研究(河流)奖以及参与超级基金和其他 NIEHS计划。M-Leead的使命是加速定义环境影响的研究 在脆弱的生命阶段进行暴露，并促进研究结果的翻译，以改善临床和公众 减轻疾病的卫生干预措施。我们的中心通过基础设施实现其使命 对采用新的跨学科方法的现有和新的调查人员提供支持，增加 了解暴露如何针对生命中脆弱的阶段。对研究的支持通过以下方式提供 综合中心计划，包括一个试点项目计划、三个设施核心和三个研究 团队加强将研究成果转化为患者和社区的应用程序，以支持 全面和综合的环境健康范式。设施核心是：综合健康科学 (IHS)；暴露评估(EA)；以及泛OMICS和数据科学(PODS)。研究团队是有组织的 关于翻译影响：累积暴露与人口健康；气候变化与健康差异； 以及毒理学机制和健康结果。研究与利益相关者的参与相结合 通过社区参与核心(CEC)建立社区，并通过我们的 职业发展计划。一个行政核心监督该中心的运作。M-Leead 努力通过四个具体目标完成其使命：1)整合机构方案和设施，以 提供结构和资源，以加速理解环境与环境之间的复杂关系 暴露、人类生物学和疾病；2)促进研究人员之间的整合与合作 传统和新兴学科进行研究，转化为改进的战略，以防止 环境引起的疾病；3)通过支持科学家建立方案和科学能力 在职业生涯的关键阶段从事解决环境健康关键问题的研究；以及4) 通过多方向的公平伙伴关系与受影响的社区接触，以确定社区 关注环境健康问题，并合作将研究成果转化为促进健康的行动。

ABSTRACT (Overall) This is a competing renewal application for the Environmental Health Sciences Core Center at the University of Michigan, submitted in the final year of our second term of support. Our Center is organized around the theme of critical windows of susceptibility to environmental exposures as important determinants of disease, forming the Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD). Lifestage, as used in this application, refers to clinically-recognized stages of development, mid-life, and aging that pertain to the pre- conception, prenatal, infant, child, adolescent, reproductive age adult, and aging adult periods. Our Center builds on a strong foundation of research activity and support in environmental health sciences, with 22 NIEHS grants and projects, including Outstanding New Environmental Health Scientist (ONES) and Revolutionizing Innovative, Visionary Environmental health Research (RIVER) awards and participation in Superfund and other NIEHS programs. The M-LEEaD mission is to accelerate research that defines impacts of environmental exposures during vulnerable life stages and to promote translation of findings to improve clinical and public health interventions for the mitigation of disease. Our Center implements its mission through infrastructural support of established and new investigators applying novel transdisciplinary approaches that increase understanding of how exposures target vulnerable stages of life. Support for research is provided through integrated Center programs that include a Pilot Project Program, three Facility Cores, and three Research Teams to enhance translation of research findings into applications for patients and communities to support a comprehensive and integrated environmental health paradigm. Facility Cores are: Integrated Health Sciences (IHS); Exposure Assessment (EA); and Pan-Omics and Data Science (PODS). Research Teams are organized around translational impact: Cumulative Exposures & Population Health; Climate Change & Health Disparities; and Toxicological Mechanisms & Health Outcomes. Research is coupled with engagement of stakeholder communities through the Community Engagement Core (CEC), and training of future leaders through our Career Development Program. An Administrative Core oversees the functioning of the Center. M-LEEaD strives to accomplish its mission through four specific aims: 1) Integrate institutional programs and facilities to provide structure and resources that accelerate understanding of complex relationships among environmental exposures, human biology, and disease; 2) Foster integration and cooperation among investigators across traditional and emerging disciplines to conduct research that translates to improved strategies to prevent environmentally-induced disorders; 3) Build programmatic and scientific capacity through support for scientists at critical career stages to engage in research that addresses critical questions in environmental health; and 4) Engage with affected communities via equitable partnerships in a multidirectional manner to identify community environmental health concerns and collaboratively translate research findings into action to promote health.