Biochemical Assay Core

药物发现和药物化学优化项目的一个主要驱动力是快速获得质量 大量化合物的生化活性数据。这些数据有助于阐明结构活性 在设计-制作-测试周期中建立关系并推动决策。生化分析核心将 负责为目标产品组合提供ASAP中心快速和广泛的生化检测。这个 CORE将建立一个强大的管道，具有最严格的检测验收标准。的迭代性质 活动意味着化合物的测试将在更长的时间段内进行。明确的协议和 需要进行控制以实现高标准的重现性。文件和质量控制将使 作为化合物和分析的资源的有效利用在相互作用的基团之间转移 财团。访问由提供的行业级自动分析、筛选和化合物收集 生化分析核心将成为ASAP中心在发现和发展 抗病毒药物。

A main driver of drug discovery and medicinal chemistry optimization projects is rapid access to quality biochemical activity data of a large number of compounds. Such data facilitates the elucidation of structureactivity relationships and drives decision making in the design-make-test cycle. The Biochemical Assay Core will be in charge of providing the ASAP Center rapid and extensive biochemical assays for the target portfolio. The Core will establish a robust pipeline with the most rigorous assay acceptance criteria. The iterative nature of the activities means that testing of compounds will be performed over an extended time period. Clear protocols and controls are required to enable a high standard of reproducibility. Documentation and quality control will enable the efficient use of resources as compounds and assays are transferred between the interacting groups in the consortium. Access to industry-level automated assays, screening and compound collections provided by the Biochemical Assay Core will be a force multiplier for the ASAP Center in the discovery and development of antiviral drugs.