Advancing Tobacco Regulatory Science to Reduce Health Disparities

摘要：总体 美国在减少吸烟方面已经取得了数十年的进展，但在薄荷醇方面仍然存在显着差异 调味产品的使用和非卷烟烟草产品的使用，包括小雪茄，小雪茄和电子烟。 香烟我们提出了U 54计划项目，“推进烟草监管科学，以减少健康 差异”来弥补这一差距。我们的ESTCORS的综合主题是建立科学， 对烟草产品过度使用的有效监管和宣传 人口-调味烟草产品和电子烟。我们的四个综合研究项目旨在 了解法规和宣传活动对烟草使用弱势群体的影响 不平等，包括黑人;低社会经济地位（SES）;和女同性恋，男同性恋或双性恋（LGB） 人口;以及青年和青年人。我们的最终目标是进一步FDA和NIH的努力，以保护公众 通过对烟草制品的监管来保护健康。TCORS的研究将提供必要的证据， 美国食品和药物管理局，因为它实施禁令的薄荷香烟和调味雪茄，发展沟通 运动，并解决青年vaping流行病。我们提出了四个具体目标：1）发展和 评估宣传运动对劝阻不同人群使用烟草制品的影响 （项目1、2、4）; 2）了解不同国家禁止加香烟草产品对公共卫生的影响。 人口和条件下，他们最有可能是最有效的（项目2和3）; 3）建立 学员通过培训、指导和试点为烟草监管科学领域做出贡献的能力 资助一个多元化和多学科的博士前研究员，博士后研究员，和早期阶段 研究人员（项目1-4，职业提升核心）; 4）告知FDA对薄荷醇香烟的监管， 通过积极传播TCORS的科学发现，禁止加香雪茄并开展宣传活动 （项目1-4，行政核心）。项目1将开展一项新颖的宣传运动， 年轻人少抽雪茄和小雪茄。项目2将评估是否可以禁止薄荷香烟。 通过戒烟运动来帮助薄荷烟吸烟者戒烟，包括黑人和LGB吸烟者。项目 3将建立一个微观模拟模型，以估计联邦风味雪茄禁令对公众健康的影响。 烟草使用、死亡率和健康差距。项目4将测试预防电子烟视频广告的能力， 有前途的功能，以减少青年和年轻人对vaping的敏感性。的研究项目 将获得两个核心的支持：行政和职业提升（其中包括试点研究 项目）。我们经验丰富的监管科学研究人员组成的多学科小组将提供可操作的 为FDA法规和宣传活动提供信息。

ABSTRACT: OVERALL The US has made decades of progress in reducing cigarette smoking, but notable disparities persist in menthol flavored product use and in the use of non-cigarette tobacco products, including little cigars, cigarillos, and e- cigarettes. We propose the U54 Program Project, “Advancing Tobacco Regulatory Science to Reduce Health Disparities” to address this gap. The Integrative Theme of our UNC TCORS is building the science for effective regulation of and communication about tobacco products disproportionately used by priority populations – flavored tobacco products and e-cigarettes. Our integrated set of four Research Projects seek to understand the impact of regulations and communication campaigns on those disadvantaged by tobacco use disparities, including Black; lower-socioeconomic status (SES); and lesbian, gay, or bisexual (LGB) populations; and youth and young adults. Our ultimate goal is to further FDA and NIH efforts to protect public health through regulation of tobacco products. UNC TCORS’ research will provide essential evidence to guide the FDA as it implements bans on menthol cigarettes and flavored cigars, develops communication campaigns, and addresses the youth vaping epidemic. We propose four Specific Aims: 1) Develop and evaluate the impact of communication campaigns to discourage tobacco product use in diverse populations (Projects 1, 2, 4); 2) Understand the public health impact of flavored tobacco product bans in diverse populations and the conditions under which they are most likely to be most effective (Projects 2 and 3); 3) Build trainees’ capacity to contribute to the field of tobacco regulatory science through training, mentorship, and pilot funding for a diverse and multidisciplinary group of pre-doctoral fellows, post-doctoral fellows, and early-stage investigators (Projects 1-4, Career Enhancement Core); 4) Inform FDA regulation of menthol cigarette and flavored cigar bans and communication campaigns through active dissemination of TCORS scientific findings (Projects 1-4, Administrative Core). Project 1 will develop a novel communication campaign to discourage young adult little cigar and cigarillo use. Project 2 will evaluate whether a menthol cigarette ban could be amplified by a quit smoking campaign to help menthol smokers quit, including Black and LGB smokers. Project 3 will build a microsimulation model to estimate the public health impact of a federal flavored cigar ban on tobacco use, mortality, and health disparities. Project 4 will test the ability of vaping prevention video ads with promising features to reduce susceptibility to vaping among youth and young adults. The Research Projects will receive support from two Cores: Administrative and Career Enhancement (which includes Pilot Research Projects). Our multidisciplinary group of seasoned regulatory science researchers will provide actionable information to inform FDA regulations and communication campaigns.