Project 3: Nicotine Product Claims on Appeal, Perceptions, and Use Behavior

摘要-项目3 口服尼古丁袋（ONP）于2016年在美国出现，ONP品牌迅速激增，销售额 暴涨ONP代表了烟草行业向销售非烟草尼古丁的转变 产品作为香烟、无烟烟草（ST）甚至电子烟（EC）的替代品。尼古丁是 使用和依赖的驱动因素，该行业不断操纵尼古丁的尺寸，以最大限度地 吸引消费者。包装是增加产品吸引力的主要营销工具，而ONP包装 突出强调尼古丁浓度（例如，3 mg、6 mg）和来源声明（例如，“无烟草”） 一种营销工具。了解这些传达尼古丁尺寸的包装特征如何影响 ONP在年轻成人非吸烟者与成人烟草使用者中的吸引力对于为ONP制定法规至关重要 以及其他使用类似营销的尼古丁产品。俄亥俄州州立大学烟草中心项目3 监管科学（OSU-TCORS）将研究尼古丁浓度和来源声明如何影响ONP 包装影响ONP的吸引力以及这些特征如何影响ONP相对于EC的偏好， 香烟，ST，和其他产品在年轻的非烟草使用者与成人烟草使用者。具体目标 1）检查尼古丁浓度和来源声明对视觉和认知参与的影响 ONP包装使用实验室为基础的心理生理评估。2)检查尼古丁的影响 浓度和源声明对ONP的看法，行为意图和ONP试验。3)探讨 尼古丁浓度和来源声明对ONP偏好相对于EC、香烟、ST和 其他烟草产品。项目3包括两项补充研究，以实现这些目标。研究1（目的 1和2）是2（年轻成人易感非使用者，成人烟草使用者）× 3（标记尼古丁浓度：无， 低，高）x3（来源声明：无，“无烟草”，“合成”）人类实验室实验，以研究如何 尼古丁浓度和来源声明影响使用ONP包装的参与， 措施，ONP上诉，风险认知和使用意图，以及行为失误任务评估ONP试验。 研究2（目标3）是一项离散选择实验，样本为全国范围内的年轻成年易感非吸毒者， 成人烟草使用者评估尼古丁浓度和来源声明对ONP偏好的影响 相对于EC、香烟、ST和其他产品。项目3解决营销影响和行为 FDA烟草监管科学领域。项目3是重要的和创新的，因为它将是一个 第一项研究，以产生证据，通知潜在的监管包装功能传达尼古丁 浓度和尼古丁来源声明，基于其在年轻成人非使用者与成人中的差异效应 烟草使用者通过与项目1、2和4的整合，OSU-TCORS将提供证据， 针对ONP、EC和其他新型产品的尼古丁维度的总体监管策略。

SUMMARY – PROJECT 3 Oral nicotine pouches (ONPs) emerged in the U.S. in 2016, ONP brands rapidly proliferated, and sales are skyrocketing. ONPs are representative of a shift by the tobacco industry to marketing non-tobacco nicotine products as alternatives to cigarettes, smokeless tobacco (ST), and even e-cigarettes (ECs). Nicotine is the driver of use and dependence, and the industry continuously manipulates nicotine dimensions to maximize appeal to consumers. Packaging is a primary marketing vehicle to increase product appeal, and ONP packaging prominently emphasizes nicotine concentration (e.g., 3 mg, 6 mg) and source claims (e.g., “tobacco free”) as a marketing tool. Understanding how these packaging features communicating nicotine dimensions affect the appeal of ONPs in young adult non-users versus adult tobacco users is critical to inform regulations for ONPs and other nicotine products using similar marketing. Project 3 of the Ohio State University Tobacco Center of Regulatory Science (OSU-TCORS) will examine how nicotine concentration and source claims on ONP packaging affect the appeal of ONPs and how these features affect preferences for ONPs relative to ECs, cigarettes, ST, and other products in young non-tobacco users versus adult tobacco users. The Specific Aims are to: 1) Examine the effects of nicotine concentration and source claims on visual and cognitive engagement with ONP packaging using laboratory-based psychophysiological assessment. 2) Examine the effects of nicotine concentration and source claims on ONP perceptions, behavioral intentions, and ONP trial. 3) Investigate the effects of nicotine concentration and source claims on ONP preferences relative to ECs, cigarettes, ST, and other tobacco products. Project 3 includes 2 complementary studies to accomplish these aims. Study 1 (Aims 1 and 2) is a 2 (young adult susceptible non-user, adult tobacco user) x 3 (labelled nicotine concentration: none, low, high) x 3 (source claim: none, “tobacco free,” “synthetic”) human laboratory experiment to examine how nicotine concentration and source claims affect engagement with ONP packaging using psychophysiological measures, ONP appeal, risk perceptions and use intentions, and a behavioral lapse task assessing ONP trial. Study 2 (Aim 3) is a discrete choice experiment with a national sample of young adult susceptible non-users and adult tobacco users to assess the effects of nicotine concentration and source claims on ONP preferences relative to ECs, cigarettes, ST, and other products. Project 3 addresses the Marketing Influences and Behavior FDA tobacco regulatory science domains. Project 3 is significant and innovative because it will be one of the first studies to generate evidence to inform potential regulation of packaging features communicating nicotine concentration and nicotine source claims based on their differential effects in young adult non-users versus adult tobacco users. Through integration with Projects 1, 2, and 4, the OSU-TCORS will provide evidence to guide an overall regulatory strategy targeting nicotine dimensions for ONPs, ECs, and other novel products.