Mentored Patient-Oriented Research on Adolescent Alcohol Misuse and Treatment

项目总结/摘要 这个K24职业中期研究和指导计划旨在为候选人提供受保护的时间， 指导患者护理，对青少年酒精滥用进行以患者为导向的研究（POR），并指导 成瘾科学转化研究的早期职业临床研究人员。迎接…的挑战 为数百万努力减少酒精使用的美国青年提供治疗选择， 这一领域需要训练有素的研究人员，他们可以整合各种前沿概念和方法， 的地区。随着我们对成瘾的理解变得越来越复杂，早期的训练需求也变得越来越复杂- 职业科学家二十多年来，这位候选人建立了一个富有成效的、不断得到资助的 POR计划，将理论驱动的假设从临床前和人类实验室研究转化为真实的 世界应用。拟议的综合计划将促进候选人指导职业生涯早期的能力 临床研究人员在POR和增强他的能力，作为一个独立的临床科学家。研究 该计划的重点是通过数字健康改善青少年酗酒的治疗选择， 通过在以下方面提供指导早期职业科学家的工具来实现指导目标： 酒精使用障碍的发病机制和治疗效果，ii）临床试验方法，iii）生态瞬时 评估方法，以及iv）负责任地开展研究的培训。候选人的目标是 进一步发展和完善实验治疗方法，产生高质量的信息， 决定是否需要进一步开发新的治疗方法。这款K24将支持 为基于黄金标准心理社会学的综合数字健康平台收集试点数据 治疗青少年AUD的干预措施。青春期是青少年精神分裂症发病的关键时期， 澳元。酒精使用通常在青春期开始，AUD的患病率在21岁之前达到峰值。然而， 尽管有临床需求，但青少年的AUD治疗依赖于心理社会干预， 效益改善青少年酒精治疗的一个潜在方法是增加现有的最佳治疗方案。 通过创新的数字健康解决方案进行社会心理干预。

PROJECT SUMMARY/ABSTRACT This K24 midcareer research and mentoring program aims to provide the candidate with protected time from direct patient care to conduct patient-oriented research (POR) on adolescent alcohol misuse and to mentor early-career clinical investigators in translational research in addiction science. To meet the challenge of advancing treatment options for the millions of American youth who struggle to reduce their alcohol use, the field requires highly trained researchers who can integrate cutting-edge concepts and methods from a variety of areas. As our understanding of addiction has become more complex, so too has the training needs of early- career scientists. For more than two decades, the candidate has built a productive and continuously funded POR program that translates theory-driven hypotheses from preclinical and human laboratory research to real world applications. The proposed integrated plan will facilitate the candidate’s ability to mentor early-career clinical investigators in POR and augment his capabilities as an independent clinician scientist. The research plan, which focuses on improving treatment options for adolescent alcohol misuse through digital health, dovetails the mentoring goals by providing a vehicle for mentoring early career scientists in: i) mechanisms of alcohol use disorder pathogenesis and treatment effects, ii) clinical trial methods, iii) ecological momentary assessment approaches, and iv) training in the responsible conduct of research. The candidate’s goal is to further develop and refine an experimental therapeutics approach that yields high quality information to inform decisions about whether further development of novel treatments is warranted. This K24 will support the collection of pilot data for an integrative digital health platform based on gold standard psychosocial interventions for treating AUD among adolescents. Adolescence is a critical period for the pathogenesis of AUD. Alcohol use typically begins during adolescence and prevalence rates for AUD peak before age 21. Yet, despite clinical demand, AUD treatments for youth rely on psychosocial interventions that yield only modest benefits. One potential way to improve adolescent alcohol treatment is to augment the best available psychosocial interventions with innovative digital health solutions.