Developing a Community-Based Facility to Support Next Generation Biomedical HIV Research

项目总结/摘要 华盛顿的7号和8号病房是美国最严重的种族不平等的地方， 社会经济指标，这些病房的居民在医疗保健方面服务不足， 公共卫生研究不足。在这些卫生不平等现象中，艾滋病毒的负担要高得多， 然而，华盛顿特区没有一个与艾滋病毒有关的主要研究设施位于这些病房内。两个中心枢纽， 华盛顿特区内的艾滋病研究--华盛顿特区艾滋病研究中心和华盛顿特区临床试验单位--都在运作 主要是在病房2的设施，这项研究的效力将得到加强， 在议定书中代表边缘化社区，以优化这项工作对 华盛顿特区受艾滋病毒、其合并症/合并感染和其他并发症打击最严重的社区 卫生不平等。因此，拟议的艾滋病毒研究设施奖的目标是资助建立一个新的 国家的最先进的，以社区为中心的临床和翻译艾滋病毒研究设施位于新的 目前正在华盛顿特区8号病房建造的惠特曼-沃克旗舰大楼，将与艾滋病毒共同使用。 惠特曼-沃克和乔治华盛顿大学（GWU）的调查人员。拟议的设施将 增加10,300平方英尺的专用研究空间，包括一个最先进的研究实验室和一个研究 具有无菌配制试验用药品能力的药房， 在这座建筑物的研究空间，并作为艾滋病毒为重点的研究， 华盛顿东南部。这样做将大大：（1）增加能够进行的研究的总量;（2） 加强惠特曼-沃克和GWU调查人员的合作，加强战略整合， 这两个研究计划;（3）扩大工作的范围和技术能力，不仅可以 对于这两个机构，但也在这些特定的社区DC;（4）间接扩大可用 社会/行为和公共卫生研究的空间，以及通过搬迁所有临床和翻译 （5）为当地社区提供更多的机会和代表性，以削减- 边缘艾滋病毒科学和新的机会，以帮助通知这些合作研究议程;（6）促进 在地方和国家政策范围内更多地翻译和传播艾滋病毒科学的突破 这将有利于当地DC社区和全国各地的社区;（7）促进新的 培训和指导的机会。总而言之，拟议的项目将对这两个方面产生倍增影响。 通过这一独特的计划，扩大现有设施的规模和范围， 并与华盛顿两个顶尖的艾滋病研究机构合作，利用现有的伙伴关系，建立新的， 以社区为中心的合作研究议程。在这样做的过程中，该奖项将带来尖端的 艾滋病毒治疗和预防科学的突破直接影响到受影响最严重的服务不足社区 艾滋病毒在华盛顿特区的流行，并在未来几十年内对公共卫生产生重大影响。

Project Summary/Abstract Wards 7 and 8 in Washington, DC are home to some of the nation’s most stark racial inequities in health and socioeconomic indicators, with residents of these wards being underserved in healthcare and underrepresented public health research. Among these health inequities is a significantly higher burden of HIV, yet none of the major HIV-related research facilities in DC are located within these wards. Two central hubs for HIV research within DC—the DC Center for AIDS Research and the DC Clinical Trials Unit—both operate primarily out of facilities in Ward 2, and the efficacy of this research would be enhanced by stronger representation of marginalized communities in protocols to optimize the impact of this work on the neighborhoods in DC that are the hardest hit by HIV, its co-morbidities/co-infections, and other co-occurring health inequities. Thus, the goal of the proposed HIV research facilities award is to fund the build-out of a new state-of-the-art, community-centered clinical and translational HIV research facility located within the new flagship Whitman-Walker building currently being constructed in DC’s Ward 8, to be used jointly by HIV investigators at both Whitman-Walker and George Washington University (GWU). The proposed facility would add 10,300 square feet of dedicated research space, including a state-of-the-art research lab and a research pharmacy with capacity for sterile compounding of investigational products, more than doubling the available space for research in this building and serving as the primary collaborative hub for HIV-focused research in Southeast DC. Doing so will significantly: (1) increase the overall volume of research able to be conducted; (2) enhance the collaboration of Whitman-Walker and GWU investigators, bolstering the strategic integration of both research programs; (3) expand the scope and technical capabilities of the work that is possible not only for both institutions but also within these specific neighborhoods of DC; (4) indirectly expand the available space for social/behavioral and public health research as well by relocating all clinical and translational research to the new facility; (5) provide local communities with greater access to and representation in cutting- edge HIV science and new opportunities to help inform these collaborative research agendas; (6) facilitate greater translation and dissemination of breakthroughs in HIV science within local and national policy contexts that will benefit both local DC communities and communities across the country; and (7) promote new opportunities for training and mentorship. In sum, the proposed project will have a multiplicative impact on both local and national HIV research through this unique plan to increase the size and scope of facilities available and co-locate two of DC’s top HIV research institutions to leverage existing partnerships and forge new, community-centered collaborative research agendas. In doing so, the award will bring cutting-edge breakthroughs in HIV treatment and prevention science directly to underserved communities most impacted by the HIV epidemic in DC and has significant potential for public health impact for decades to come.