Data-driven, peer-led messaging using social media influencers to increase PrEP awareness and uptake among transgender women

项目摘要 跨性别女性（TW）感染艾滋病毒的风险明显更高，但研究表明， 可能使用暴露前预防（PrEP），并继续对其效用存在误解。反式- 由可信赖的同行提供的包容性通信是解决这一差距的潜在有用战略，但 接触大量TW可能很困难。SIS（姐妹篇影响姐妹篇）研究将使用 来自NIMH资助的R21的初步发现，该研究利用了称为感知的商业营销技术， 映射和矢量消息建模，以开发和概念测试TW特定的PrEP消息。使用 以《性别平等肯定框架》和《性别平等信息系统实施框架》为指导，我们建议在《性别平等框架》中 这些测试了SIS干预中的PrEP信息和材料，并使用TW社会影响者（SI）进行试点 通过Instagram。研究的具体目标是：目标1：设计一个社区主导的，基于社交媒体的PrEP TW SI的消息传递培训。我们将招募一个社区咨询委员会（CAB）， 研究的各个方面，包括制定统计调查员培训和招聘统计调查员、工具/措施， 传播研究结果，并为未来的试验提供投入。目标2：完善PrEP信息材料，设计SIS 干预模块，并识别和培训TW SI。我们将最终确定PrEP信息材料， 跨艺术家来优化图像并转换为社交媒体格式。在CAB的帮助下，我们将识别并 在社交媒体上与来自两个干预地点（旧金山弗朗西斯科湾、费城）和两个 比较地点（纽约和洛杉矶）。干预SI将接受有关SIS干预的培训 内容以及向社区提供临床转诊和资源。目标3：目标3：试点测试 SIS干预，收集可行性、可接受性和初步疗效数据，为全面试验提供信息。我们 将实施基于Instagram的干预措施的标准化核心组成部分，评估传播情况， 覆盖PrEP信息，并监测和评估与材料的接触。评估...的承诺 疗效，我们将确定一个队列的120名追随者（80干预，40比较），以完成基线，中期和 干预结束调查，以跟踪变化，并比较PrEP知识和PrEP观念的水平。我们 还将试点远程收集头发样本，以监测参与者子样本中PrEP的吸收和使用 （n = 30;每个SI 5）并进行深入干预实施评价。我们预计，调查结果将 大大有助于我们理解如何与不同的TW群体进行沟通，如何利用 社交媒体作为强大的沟通渠道，以及如何传播信息以增加PrEP 通过解决TW独特的艾滋病毒预防需求和关切，提高认识和吸收。

Project Summary Transgender women (TW) are at significantly higher risk of getting HIV, yet research indicates they are less likely to use pre exposure prophylaxis (PrEP) and continue to have misconceptions about its utility. Trans- inclusive communication, delivered by trusted peers, is a potentially useful strategy to address this gap, but reaching a large number of TW can be difficult. The SIS (Sisters Influencing Sisters) study will use preliminary findings from a NIMH funded R21 that utilized commercial marketing techniques called perceptual mapping and vector message modeling to develop and concept test TW specific PrEP messages. Using the Gender Affirmation Framework and the EPIS Implementation Framework as guides, we propose to embed these tested PrEP messages and materials in the SIS intervention and pilot it using TW social influencers (SIs) via Instagram. Specific aims of the research are: Aim 1: Design a community-led, social-media based PrEP messaging training for TW SIs. We will recruit a Community Advisory Board (CAB) who will consult on all aspects of the study, including the development of an SI training and recruitment of SIs, tools/measures, dissemination of findings, and input on a future trial. Aim 2: Refine PrEP messaging materials, design the SIS intervention modules, and identify and train TW SIs. We will finalize PrEP messaging materials, engaging trans artists to refine images and convert to social media formats. With the help of our CAB, we will identify and engage SIs on social media from two intervention locations (San Francisco Bay, Philadelphia) and two comparison locations (New York and Los Angeles). Intervention SIs will be trained on the SIS intervention content as well as delivery of clinical referrals and resources to their communities. Aim 3: Aim 3: Pilot test the SIS intervention to collect feasibility, acceptability, and preliminary efficacy data to inform a full trial. We will implement standardized core components of the Instagram-based intervention, evaluate dissemination and reach of the PrEP messages, and monitor and evaluate engagement with the materials. To assess promise of efficacy, we will identify a cohort of 120 followers (80 intervention, 40 comparison) to complete baseline, mid and end of intervention surveys to track changes and compare levels of PrEP knowledge and PrEP perceptions. We will also pilot remote collection of hair samples to monitor PrEP uptake and use in a subsample of participants (n=30; 5 each SI) and do in-depth intervention implementation evaluation. We expect that findings will significantly contribute to our understanding of how to communicate with a diverse group of TW, how to leverage social media as a powerful communication channel, and how to disseminate information to increase PrEP awareness and uptake by addressing the unique HIV prevention needs and concerns of TW.