NeuroHIV and Community Partnership and Disparity Core for Institution # 269291

摘要 尽管许多艾滋病毒携带者(PWH)通过抗逆转录病毒治疗(ART)很好地抑制了感染，但一些人 威尔斯亲王医院的人群在参与艾滋病毒护理连续体方面与及时感染艾滋病毒的人群存在差异 病毒抑制的诊断。这些差异，特别是延迟启动抗逆转录病毒疗法和中断艾滋病毒 护理和抗逆转录病毒治疗的坚持，可能会使被认为处于风险或难以接触到的人群面临进一步的神经艾滋病毒风险- 相关并发症，包括神经认知障碍和神经行为后遗症以及其他 并存的临床问题。减少与艾滋病毒有关的健康差距和健康不平等是四个目标之一 国家艾滋病毒/艾滋病战略的执行情况。综合神经艾滋病毒中心(CNHC)不仅定位良好， 支持针对神经性艾滋病毒机制的研究，但也支持如何促进令人兴奋的跨学科 合作调查、预防、治疗和解决可能对神经性艾滋病毒有重大贡献的差异- 边缘化人群中的相关疾病。通过支持社区参与的研究范式，CNHC 将使神经艾滋病毒科学家的研究对受健康差距影响的人群产生最大影响，同时 利用社区成员关于他们的需求、优势和经验的专业知识。因此，在这次更新中， 我们发起了神经艾滋病毒社区伙伴关系和差异核心(NHCPDC)，以促进社区- 合作伙伴关系和跨学科协作，检查、解决和防止涉及以下方面的差异 神经艾滋病毒。NHCPDC的目标是(1)进行社区需求评估，以完善核心的研究 基础设施服务；(2)作为指导有文化能力的研究的主要资源 社区和解决神经艾滋病毒的差异；以及(3)双向传播研究成果 与当地和更广泛的社区沟通，以解决神经性艾滋病毒的差异。NHCPDC将发挥作用 与中央行政和管理核心协同配合，通过协助研究来补充其支持 涉及神经艾滋病毒差异；发展研究和导师核心，以支持不同的群体 研究人员和NHCPDC相关研究；以及临床和转译研究支持核心，以增强 它为有文化能力的研究提供服务，并扩大其招聘努力，使其人数不足 罹患神经艾滋病毒风险较高的群体；以及包括病毒基因编辑和生物信息学在内的所有核心 核心和细胞生物学和功能分析核心，以帮助传播研究结果并促进社区 提高对神经性艾滋病毒发展的认识和参与。核心将增加 跨学科合作以及由此产生的研究和出版物。在与其他内核的协同中， NHCPDC将通过支持与以下方面相关的研究来提高神经艾滋病毒研究企业的质量 神经性HIV的差异和预防、治疗和了解神经性HIV疾病的HIV护理的连续性 边缘人群面临的风险最大。

SUMMARY Despite many people with HIV (PWH) having well-suppressed infection with antiretroviral treatment (ART), some populations of PWH experience disparities in their engagement in the HIV care continuum from timely HIV diagnosis to viral suppression. These disparities, particularly the delayed initiation of ART and disruptions to HIV care and ART adherence, may place populations deemed at risk or hard to reach at further risk of neuroHIV- related complications, including neurocognitive impairments and neurobehavioral sequelae as well as other comorbid clinical problems. Reducing HIV-related health disparities and health inequities is one of the four goals of the National HIV/AIDS Strategy. The Comprehensive NeuroHIV Center (CNHC) is well-positioned not only to support research that addresses the mechanisms of neuroHIV, but also how to facilitate exciting interdisciplinary collaborations to investigate, prevent, treat, and address disparities that may contribute significantly to neuroHIV- related disease in marginalized populations. By supporting a community-engaged research paradigm, the CNHC will maximize the impact of neuroHIV scientists’ research for populations affected by health disparities while leveraging community members’ expertise about their needs, strengths, and experiences. Thus, in this renewal, we have initiated the NeuroHIV Community Partnership and Disparities Core (NHCPDC) to foster community- partnership and interdisciplinary collaborations that examine, address, and prevent disparities involving neuroHIV. The NHCPDC will aim to (1) conduct a community needs assessment to refine the Core’s research infrastructure services; (2) serve as a primary resource to guide culturally competent research that engages communities and addresses neuroHIV disparities; and (3) disseminate research findings in bidirectional communication with the local and broader community to address neuroHIV disparities. The NHCPDC will work in synergy with the Central Administrative and Management Core to complement its support by aiding research involving neuroHIV disparities; the Developmental Research and Mentorship Core to support a diverse group of researchers and NHCPDC-related studies; and the Clinical and Translational Research Support Core to enhance its services for culturally competent research and expand its recruitment efforts involving underrepresented groups at greater risk of developing neuroHIV; and all Cores, including the Viral Gene Editing and Bioinformatics Core and the Cell Biology and Functional Analysis Core, to help disseminate findings and facilitate community awareness and involvement with respect to the development of neuroHIV. The Core will increase the number of interdisciplinary collaborations and resulting studies and publications. In synergy with the other Cores, the NHCPDC will enhance the quality of the neuroHIV research enterprise by supporting research related to neuroHIV disparities and the continuum of HIV care to prevent, treat, and understand neuroHIV disease in marginalized populations most at risk.