Core 3: Bioinformatics and Biostatistics Core

摘要 Emory肺癌P01的应用旨在破译免疫治疗的潜在机制 LKB1-MUT肺癌的耐药性和三个相互关联的项目寻求可能的治疗方案 以解决这一紧急的未得到满足的医疗需求。生物信息学和生物统计学核心(核心)的功能 3)提供稳健和透明的分析战略、复杂和综合的数据分析和 管理平台和最先进的方法，以最大限度地提高整个计划的成功 通过指导和促进数据驱动的交互和协作。为了支持这一目标，我们的Core 3团队 拥有互补的专业知识和丰富的经验，在生物统计学、生物信息学和 医学信息学和数据管理，对严格的实验设计和简化数据至关重要 分析、解释、共享和管理基本机制驱动的检查和临床研究。 具体地说，我们将(I)提供全面的生物统计学专业知识和资源，以支持肺癌 P01项目，包括新的临床试验设计；(Ii)提供新的综合计算平台，以支持 GDH1(项目1)、IAP/STIN(项目2)和FAK(项目3)分子基础的阐明- 与项目负责人一起研究LKB1缺陷肺癌的依赖肿瘤发生；以及(Iii)制定和维持一项 为本P01专门定制的集中数据采集和管理系统。核心3作为 P01的一个联络点，以确保数据的完整性、科学的严密性和共享；并促进 基于对机制和临床结果的综合分析并与每个项目密切互动的项目 和核心1和核心2通过共享数据库。作为P01计划的关键组成部分，核心 3将是进一步保障和提升P01整个研究质量的关键，以支持发展 LKB1患者新一代有效的抗癌免疫治疗策略 突变的肺癌。

SUMMARY The Emory Lung Cancer P01 application aims to decipher the underlying mechanisms of immunotherapy resistance of LKB1-mut lung cancer and to seek possible therapeutic solutions with three interconnected projects to address this urgent unmet medical need. The function of the Bioinformatics and Biostatistics Core (Core 3) is to provide robust and transparent analytic strategies, sophisticated and integrated data analysis and management platforms, and state-of-the-art methodologies to maximize the success of the overall program through guiding and fostering data-driven interactions and collaborations. To support this goal, our Core 3 team of investigators has complementary expertise and extensive experience in biostatistics, bioinformatics, and medical informatics and data management that is critical for rigorous experimental design and streamlined data analysis, interpretation, sharing and management for basic mechanism-driven examination and clinical studies. Specifically, we will (i) provide comprehensive biostatistical expertise and resources in support to Lung Cancer P01 projects, including novel clinical trial design; (ii) provide a new integrative computational platform to support the elucidation of the molecular basis for GDH1 (Project 1), IAP/STING (Project 2), and FAK (Project 3)- dependent tumorigenesis in LKB1-deficient lung cancer with project leaders; and (iii) develop and maintain a centralized data acquisition and management system that is customized explicitly for this P01. Core 3 serves as a focal point of the P01 to ensure data integrity, scientific rigor, and sharing; and to foster collaborations between projects based on integrated analysis of mechanistic and clinical results and close interactions with each project and Core 1 and Core 2 through a shared database. Serving as a critical component of the P01 Program, Core 3 will be critical to further safeguard and elevate the entire research quality in this P01 to support the development of the next generation of effective anticancer immunity-based therapeutic strategies for patients with LKB1 mutated lung cancer.