Environmental Carcinogenesis and Mutagenesis

本申请是为了更新T32 ES-09250-30培训补助金，题为“环境致癌作用和 自1986年成立以来一直在Stambrook博士的指导下进行。阿尔瓦罗医生 Puga，联合PI，自该计划成立以来一直是该计划的导师，并担任助理 他在过去五年预算期间担任主任，他将继续担任这一职务。ECM培训计划最初 正如其标题所暗示的那样，专门侧重于环境致癌和诱变。随后 程序在科学上和概念上都得到了发展。当NIEHS指导它的时候， 与一个更小的毒理学培训项目合并该计划在科学上变得更加多样化， 对受训者来说是无价的ECM计划尽一切努力保持这种学科的广度 加强学员之间的思想和技术交流。因此，学员能够 从遗传学、细胞生物学和毒理学的角度讨论环境暴露的影响， 最终在人类疾病的背景下，包括癌症。为了保护这一广泛的学科， 该计划保持了26名参与教师，他们来自12个不同的部门/部门， 辛辛那提大学医学院（UCCOM）或辛辛那提儿童医院医疗中心 （CCHMC）。这两所院校的教师之间有非常密切的工作关系， CCHMC的教师都在UCCOM的儿科任职。承诺向企业内容管理提供的财政支助 从这两个机构的招聘和其他培训相关的费用证明了这种紧密的关系 并支持ECM。ECM继续建立在其过去的成功，其毕业生人口 学术、监管和行业领导职位。它还继续满足国家对培训的需求， 与生物学、肿瘤学和毒理学终点有关的环境接触的影响 人类疾病。自成立以来，该方案一直强调征聘任职人数不足的人， 少数民族，并在这奋进取得了成功。在制度上，该计划汇集了研究 几个实验室努力提供对接触和环境健康的共同关注，并促进 这些实验室之间的合作。企业内容管理鼓励受训人员从事研究， 几个实验室和机构研究核心的专业知识。我们每两周开一次会 或者提出他们自己的数据或专题文件加强这些互动。博士预科生都有 相当于化学，生物或物理科学的本科专业，具有上级学术 成绩许多人在该计划中获得了奖项和认可。我们选择博士后候选人 他们拥有博士学位，D.V.M.或者医学博士基于学术成就， 我们从全国范围内的申请者中挑选实习生。这份更新申请要求8名 博士前和四个博士后职位，我们发现这个计划的使命和目标的最佳规模。

This application is to renew the T32 ES-09250-30 training grant entitled, “Environmental Carcinogenesis and Mutagenesis” (ECM) which has been under the direction of Dr. Stambrook since its inception in 1986. Dr. Alvaro Puga, the Co-PI, has been a mentor in the Program since early in its history and has served as Associate Director for the past five-year budget period, a role in which he will continue. The ECM training program initially focused exclusively on environmental carcinogenesis and mutagenesis as its title implied. Subsequently, the Program has evolved scientifically and conceptually. It grew to its current optimal size when the NIEHS directed that it merge with a smaller training program in toxicology. The Program became scientifically more diverse which has proven invaluable to the trainees. The ECM program makes every effort to retain this breadth of disciplines to enhance cross-fertilization of ideas and techniques between the trainees. Thus, the trainees are able to discuss cogently the impact of environmental exposures in terms of genetics, cell biology and toxicology and ultimately in the context of human disease, including cancer. To preserve this wide range of disciplines, the Program maintains a participating faculty of 26 who derive from 12 different departments/divisions from the University of Cincinnati College of Medicine (UCCOM) or the Cincinnati Children's Hospital Medical Center (CCHMC). There is a very close working relationship between the faculty of these two institutions, and the CCHMC faculty all have appointments in pediatrics at UCCOM. The financial support committed to the ECM from both institutions for recruitment and for other training-related expenses exemplifies this tight relationship and support for the ECM. The ECM continues to build on its past successes, with its graduates populating academic, regulatory and industry leadership positions. It also continues to fulfill a national need to train individuals in the impact of environmental exposure relating to biological, oncological and toxicological endpoints and human disease. Since its inception, the Program has emphasized recruitment of under-represented minorities, and has been successful in this endeavor. Institutionally, the Program brings together the research efforts of several laboratories to provide a common focus on exposure and environmental health, and facilitates collaborations between these laboratories. The ECM encourages trainees to engage in research that combines the expertise of several laboratories and institutional research cores. Our biweekly meetings where trainees alternatively present their own data or a topical paper reinforce these interactions. Pre-doctoral trainees all have the equivalent of an undergraduate major in a chemical, biological or physical science with superior academic achievements. Many have won awards and recognition while in the Program. We select postdoctoral candidates who hold the degrees of Ph.D., D.V.M. or M.D., based on proven academic accomplishments, and like predoctoral fellows, we select trainees from a national pool of applicants. This renewal application requests eight pre-doctoral and four postdoctoral positions, a size that we find optimal for the mission and goals of this Program.