Summer Endocrine Research Training Program

摘要： 这是一份T35短期医学生暑期培训计划的竞争性续签申请 NIDDK资助了15年的内分泌研究。两个具体目标是：1)提供 在结构化指导下对医学生进行基础和临床内分泌相关研究的动手培训 环境；2)提供互动的教育体验，向医学生介绍 基础、翻译和临床内分泌相关研究所需的基本技能。该计划有 支持对6名二年级医学生进行包括糖尿病在内的内分泌研究主题的培训 特别关注糖尿病肾病、内分泌恶性肿瘤、脑垂体肽类激素的调节 表现、非酒精性脂肪性肝病、糖尿病和肥胖的心血管并发症、激素 新陈代谢的调节和干细胞生物学。实习生是从伊利诺伊大学一年级学生中挑选出来的 路易斯维尔医学院申请夏季研究学者项目(SRSP)。一位成功的 已经努力招收来自代表性不足的少数族裔和弱势背景的学生。 学生们审阅28位教师研究导师提交的可用项目，并输入他们的第一到第三个选择， 允许学员与导师配对。实习生和导师之间的面对面会面确保了他们的“契合度” 在春季学期中期。在为期10周的暑期培训中，学生们与导师合作 临床或实验室环境中的研究项目，完成负责任的研究行为培训， 包括管理科学数据、捏造和伪造数据、剽窃、出版做法和 负责任的作者、导师、管理和利益冲突。受训人员与人类一起工作 受试者完成人体科目和IRB训练。在导师实验室中使用脊椎动物的受训者 完成并通过IACUC培训课程。所有受训人员参加每周一次的夏季内分泌研究 介绍内分泌学临床/转化性研究的培训班。一个重要的组成部分- T35教师导师在这门课上讨论了提高重复性的方法。这个 课程的高潮是每个学员向同行和导师展示他/她的研究项目。受训人员也 在为期一周的研究路易斯维尔庆祝活动上，他们以海报的形式展示他们的研究成果。 海报大赛的优胜者有机会参加全国学生研究论坛 追随春天。学员可以选择继续研究，作为区别研究(DIR)路径的一部分 丰富计划，在整个医学院课程中提供研究经验，包括在 第三年和第四年，朝着培养临床医生-科研人员的目标迈进。学员们已经发表了 在同行评议的期刊上和/或在国家或国际论坛上展示他们的研究，许多人 在他们的医学院毕业证书上收到了DIR符号。跟踪实习生的职业生涯结果，以评估 这项T35计划对内科科学家职业生涯的影响。

Abstract: This is a competing renewal application for a T35 short term medical student summer training program in endocrine research that has been funded by NIDDK for 15 years. The 2 Specific Aims are 1) To provide hands-on training in basic and clinical Endocrine-related research to medical students in a structured mentored environment; 2) To provide an interactive, educational experience that introduces medical students the fundamental skills necessary for basic, translational, and clinical Endocrine-related research. The program has supported the training of 6 second year medical students in endocrine research topics including diabetes – with a particular focus on diabetic kidney disease, endocrine malignancies, pituitary regulation of peptide hormone expression, non-alcoholic fatty liver disease, cardiovascular complications of diabetes and obesity, hormonal regulation of metabolism, and stem cell biology. Trainees are selected from the first year class at University of Louisville School of Medicine (SOM) applying for the summer research scholar program (SRSP). A successful effort has been made to recruit students from underrepresented minorities and disadvantaged backgrounds. Students review the available projects submitted by 28 faculty research mentors and enter their 1st-3rd choices, allowing matching of trainees with mentors. In-person meetings between trainees and mentors assures the ‘fit’ in the middle of the Spring semester. During the 10 week summer training, students work with mentors on research projects in clinical or laboratory settings, complete training in the Responsible Conduct of Research, including managing scientific data, fabrication and falsification of data, plagiarism, publication practices and responsible authorship, mentorship, stewardship, and conflict of interest. Trainees working with human subjects complete human subject and IRB training. Trainees who use vertebrate animals in mentors’ labs complete and pass IACUC training courses. All trainees attend a weekly Summer Endocrine Research Training Class to introduce clinical/translational research in endocrinology. An essential component well- integrated into this class by T35 faculty mentors is discussion of methods for enhancing reproducibility. The Class culminates with each trainee presenting his/her research project to peers and mentors. Trainees also present their research results as posters at a SOM-wide, week-long celebration of Research!Louisville. Winners from the poster contest have the opportunity to attend the National Student Research Forum the following Spring. Trainees may choose to continue research as part of the Distinction in Research (DIR) track enrichment program that provides research experiences throughout the medical school curriculum, including in the third and fourth years, toward the goal of developing clinician-researchers. Student trainees have published in peer reviewed journals and/or presented their research in national or international forums and many have received the DIR notation on their medical school diplomas. Trainee career outcomes are tracked to assess the impact of this T35 program on careers as physician-scientists.