Animal Core

项目摘要/摘要(动物模型和表型核心) 动物模型和表型核心(AMPC)支持NORC主题的基于动物的研究 营养、肥胖和新陈代谢健康贯穿一生。这些服务主要集中在两个领域：1) 对啮齿动物基因表达的受控操纵，以及2)提供最先进的体内代谢和 行为表型。在过去的供资周期中，资产管理方案一直是整个特派团的一个关键组成部分 Pennington/Louisiana NORC，加强和促进资助的研究，同时也刺激新的和 与营养和肥胖相关的创新研究。AMPC对于范围广泛的研究是必不可少的 NORC在上一个周期中支持了36个NIDDK和其他NIH赠款，同时也密切互动 以管理核心、分子机制核心和人类表型核心确保成功 在实现每个研究项目的具体目标方面。这一关键支持将在当前周期中持续下去。 通过：a)继续利用转基因和基因打靶技术来产生模仿人类的啮齿动物模型 代谢性疾病状态；B)使用最先进的设备和技术进行详细的体内代谢 和行为表型，以及；c)提供与啮齿动物营养和肥胖研究有关的咨询， 在使用实验服务方面进行培训，并寻求新的方法和实验范例 预测NORC成员以及试点和可行性项目的需求。通过这些目标，AMPC将 在转化性研究中直接支持使用动物模型来更好地了解人类疾病状态 同时还促进了专注于营养和肥胖研究的科学家之间的相互交流。

PROJECT SUMMARY / ABSTRACT (ANIMAL MODELS & PHENOTYPING CORE) The Animal Models and Phenotyping Core (AMPC) supports animal-based studies across the NORC theme of “Nutrition, Obesity and Metabolic Health through the Lifespan”. These services focus on two primary areas: 1) the controlled manipulation of gene expression in rodents, and 2) provide state-of-the-art in vivo metabolic and behavioral phenotyping. Over past funding cycles, the AMPC has been a key component of the overall mission of the Pennington/Louisiana NORC, enhancing and facilitating funded research while also stimulating new and innovative research related to nutrition and obesity. The AMPC is essential for a broad range of research within the NORC, supporting more than 36 NIDDK and other NIH grants in the past cycle while also interacting closely with the Administrative Core, Molecular Mechanisms Core, and the Human Phenotyping Core to assure success in achieving the Specific Aims of each research project. This critical support will be sustained in the current cycle by: A) continuing to utilize transgenic and gene targeting techniques to generate rodent models that mimic human metabolic disease states; B) using state of the art equipment and technology to conduct detailed in vivo metabolic and behavioral phenotyping, and; C) providing consultation related to rodent nutrition and obesity research, training in the use of experimental services, and pursuing new methods and experimental paradigms that anticipate the needs of NORC members and Pilot and Feasibility projects. Through these goals, the AMPC will directly support the use of animal models to better understand human disease states in a translational research approach while also facilitating cross-talk among scientists focused on nutrition and obesity research.