Impact of climate change and land use on snakebite envenoming in the Brazilian Amazon

摘要 每年死亡人数高达13.8万人，永久性残疾人数40万人， 毒蛇咬伤(SBE)对中低收入国家低资源区的影响 (LMIC)。与其他非关税壁垒一样，SBE本质上与环境有关，最近 气候变化的影响。与气候有关的事件或土地利用变化，因砍伐森林或 农业生产的增长，影响了人与蛇相遇的风险 和SBE。在我们的R21毒蛇咬伤抗蛇毒血清干预期间，需要保证 (节约)项目，我们正在开发一种创新的多尺度干预措施，适时优化 提供SBE护理，包括在现有社区卫生保健中分发抗蛇毒血清 中心(CHC)在巴西亚马逊地区的网络。我们在R21附录中的目标是 利用我们目前的节约数据存储库工作来研究土地使用和 气候变化与SBE的发生、严重程度和护理需求。我们将把土地利用和 气候变化数据和我们当前的数据来源，并分析它们与SBE在 巴西亚马逊。

Abstract With as many as 138,000 deaths, and 400,000 people with permanent disabilities annually, snakebite envenoming (SBE) impacts low resource areas of low and middle income countries (LMICs). As with other NTDs, SBEs are intrinsically related to the environment and recent impact of climate change. Climate related events or land use changes, due to deforestation or the growth of agricultural production, have impacted the risk of human and snake encounters and SBE. During our R21 Snakebite Antivenom Intervention A need to be Guaranteed (SAVING) project, we are developing an innovative multi-scale intervention optimizing timely SBE care delivery, including antivenom distribution among existing community healthcare centers (CHCs) network in the Brazilian Amazon. Our goal for this R21 supplement is to leverage our current SAVING data repository efforts to study the association of land usage and climate change with SBE occurrence, severity and care needs. We will combine land usage and climate change data with our current data sources and analyze their association with SBE in the Brazilian Amazon.